Departamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Mexico City 04510, Mexico.
Int J Mol Sci. 2021 Dec 28;23(1):304. doi: 10.3390/ijms23010304.
Surface modification of polypropylene (PP) films was achieved using gamma-irradiation-induced grafting to provide an adequate surface capable of carrying glycopeptide antibiotics. The copolymer was obtained following a versatile two-step route; pristine PP was exposed to gamma rays and grafted with methyl methacrylate (MMA), and afterward, the film was grafted with -vinylimidazole (NVI) by simultaneous irradiation. Characterization included Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), and physicochemical analysis of swelling and contact angle. The new material (PP--MMA)--NVI was loaded with vancomycin to quantify the release by UV-vis spectrophotometry at different pH. The surface of (PP--MMA)--NVI exhibited pH-responsiveness and moderate hydrophilicity, which are suitable properties for controlled drug release.
采用γ射线辐照接枝的方法对聚丙烯（PP）薄膜进行表面改性，以提供足够的能够携带糖肽抗生素的表面。该共聚物是通过灵活的两步法获得的；首先将原始 PP 暴露于γ射线下，并与甲基丙烯酸甲酯（MMA）接枝，然后通过同时辐照将薄膜接枝上 -乙烯基咪唑（NVI）。表征包括傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）、热重分析（TGA）、X 射线光电子能谱（XPS）以及溶胀和接触角的物理化学分析。将新的材料（PP--MMA）--NVI 负载万古霉素，通过在不同 pH 值下的紫外-可见分光光度法定量释放。（PP--MMA）--NVI 的表面呈现出 pH 响应性和适度的亲水性，这是适合控制药物释放的特性。
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