Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China.
Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou 215123, China.
Molecules. 2020 Nov 30;25(23):5649. doi: 10.3390/molecules25235649.
The development of precise and personalized medicine requires novel formulation strategies to deliver the therapeutic payloads to the pathological tissues, producing enhanced therapeutic outcome and reduced side effects. As many diseased tissues are feathered with acidic characteristics microenvironment, pH-sensitive biomaterials for drug delivery present great promise for the purpose, which could protect the therapeutic payloads from metabolism and degradation during in vivo circulation and exhibit responsive release of the therapeutics triggered by the acidic pathological tissues, especially for cancer treatment. In the past decades, many methodologies, such as acidic cleavage linkage, have been applied for fabrication of pH-responsive materials for both in vitro and in vivo applications. In this review, we will summarize some pH-sensitive drug delivery system for medical application, mainly focusing on the pH-sensitive linkage bonds and pH-sensitive biomaterials.
精准医学和个性化医疗的发展需要新的制剂策略，将治疗有效载荷递送到病变组织，从而产生增强的治疗效果和减少的副作用。由于许多患病组织都具有酸性特征的微环境，因此用于药物输送的 pH 敏感生物材料具有很大的应用前景，它可以保护治疗有效载荷在体内循环过程中免受代谢和降解，并在酸性病变组织触发时响应性地释放治疗药物，特别是用于癌症治疗。在过去的几十年中，已经应用了许多方法，如酸性裂解键，用于制备用于体外和体内应用的 pH 响应材料。在这篇综述中，我们将总结一些用于医疗应用的 pH 敏感药物输送系统，主要集中在 pH 敏感键合和 pH 敏感生物材料上。
