Baroni C D, Pescarmona E, Calogero A, Cassano A M, Pezzella F, Barsotti P, Gallo A, Ruco L P
Section of Immunopathology, University of Rome La Sapienza, Italy.
Histopathology. 1987 Nov;11(11):1121-32. doi: 10.1111/j.1365-2559.1987.tb01853.x.
Ten cases of non-Hodgkin's lymphomas, mainly composed of large multilobated cells, have been studied. Our results are consistent with the view that they represent a somewhat heterogeneous group of lymphoid tumours displaying different morphological, clinical and immunophenotypic features. In B-cell type the large multilobated cells were histologically characterized by prominent nucleoli and distinctly basophilic cytoplasm whereas in the T-cell type they had indistinct or small nucleoli and ill-defined weakly eosinophilic cytoplasm. These differential features between B- and T-cell type were confirmed by electron microscopy. From a clinical standpoint B-cell type was characterized by a constant involvement of lymphoid tissues (lymph nodes and/or Waldeyer's ring); T-cell type showed, on the contrary, a more frequent involvement of extra-lymphoid sites (mainly bone and subcutaneous tissues). Our study provides some morphological features that may be helpful for a correct differential diagnosis in this heterogeneous group of non-Hodgkin's lymphomas.
对10例主要由多叶大细胞组成的非霍奇金淋巴瘤进行了研究。我们的结果与以下观点一致，即它们代表了一组在形态、临床和免疫表型特征上有所不同的异质性淋巴瘤。在B细胞型中，多叶大细胞在组织学上的特征是核仁突出，胞质明显嗜碱性，而在T细胞型中，它们的核仁不明显或较小，胞质界限不清且轻度嗜酸性。B细胞型和T细胞型之间的这些差异特征通过电子显微镜得到了证实。从临床角度来看，B细胞型的特征是淋巴组织（淋巴结和/或瓦尔代尔环）持续受累；相反，T细胞型显示淋巴外部位（主要是骨骼和皮下组织）受累更为频繁。我们的研究提供了一些形态学特征，可能有助于对这组异质性非霍奇金淋巴瘤进行正确的鉴别诊断。
