O'Hara C J, Said J W, Pinkus G S
Hum Pathol. 1986 Jun;17(6):593-9. doi: 10.1016/s0046-8177(86)80131-9.
The clinical, pathologic, and immunologic features in nine cases of non-Hodgkin's lymphoma of the multilobated B-cell type are described. Clinical and phenotypic heterogeneity was observed in these B-cell neoplasms. A probable follicular center cell derivation for these cytologically unusual B-cell lymphomas is supported by antecedent histories of follicular center cell neoplasms in three cases; a focal nodular pattern in one case; the demonstration of peanut lectin (PNA) receptors, a marker for follicular center cells, on neoplastic multilobated B cells; and immunoultrastructural studies of nonneoplastic tonsillar cells that identified and characterized rare multilobated cells, immunoreactive for B1, B2, and Ia membrane antigens, a phenotype consistent with follicular center-type cells. Comparison of B- and T-cell multilobated lymphomas revealed that only immunologic studies accurately discriminated between these neoplasms.
本文描述了9例多叶B细胞型非霍奇金淋巴瘤的临床、病理和免疫特征。在这些B细胞肿瘤中观察到临床和表型的异质性。这些细胞学上不寻常的B细胞淋巴瘤可能起源于滤泡中心细胞，依据如下：3例患者有滤泡中心细胞瘤的既往病史；1例呈现局灶性结节模式；在肿瘤性多叶B细胞上发现了滤泡中心细胞的标志物花生凝集素（PNA）受体；以及对非肿瘤性扁桃体细胞的免疫超微结构研究，该研究鉴定并表征了罕见的多叶细胞，这些细胞对B1、B2和Ia膜抗原有免疫反应，其表型与滤泡中心型细胞一致。B细胞和T细胞多叶淋巴瘤的比较显示，只有免疫研究能够准确区分这些肿瘤。
