Meng Shiyun, Rouabhia Mahmoud, Zhang Ze
Department of Materials Science and Engineering, College of Environment and Resources, Chongqing Technology and Business University, Chongqing 400067, China.
Département de Chirurgie, Faculté de Médecine, Axe Médecine Régénératrice, CHU de Québec-Université Laval, Quebec, QC G1V 0A6, Canada.
Materials (Basel). 2021 Dec 27;15(1):165. doi: 10.3390/ma15010165.
Research on the cellular response to electrical stimulation (ES) and its mechanisms focusing on potential clinic applications has been quietly intensified recently. However, the unconventional nature of this methodology has fertilized a great variety of techniques that make the interpretation and comparison of experimental outcomes complicated. This work reviews more than a hundred publications identified mostly from Medline, categorizes the techniques, and comments on their merits and weaknesses. Electrode-based ES, conductive substrate-mediated ES, and noninvasive stimulation are the three principal categories used in biomedical research and clinic. ES has been found to enhance cell proliferation, growth, migration, and stem cell differentiation, showing an important potential in manipulating cellular activities in both normal and pathological conditions. However, inappropriate parameters or setup can have negative effects. The complexity of the delivered electric signals depends on how they are generated and in what form. It is also difficult to equate one set of parameters with another. Mechanistic studies are rare and badly needed. Even so, ES in combination with advanced materials and nanotechnology is developing a strong footing in biomedical research and regenerative medicine.
近期，针对电刺激（ES）的细胞反应及其机制，聚焦潜在临床应用的研究已悄然加强。然而，这种方法的非常规性质催生了各种各样的技术，使得实验结果的解释和比较变得复杂。本研究回顾了主要从Medline数据库中筛选出的一百多篇文献，对这些技术进行了分类，并对其优缺点进行了评述。基于电极的电刺激、导电基质介导的电刺激和非侵入性刺激是生物医学研究和临床中使用的三个主要类别。已发现电刺激可增强细胞增殖、生长、迁移和干细胞分化，在正常和病理条件下操纵细胞活动方面显示出重要潜力。然而，不适当的参数或设置可能会产生负面影响。所传递电信号的复杂性取决于其产生方式和形式。此外，很难将一组参数与另一组参数等同起来。机理研究很少且急需开展。即便如此，电刺激与先进材料和纳米技术相结合，正在生物医学研究和再生医学领域站稳脚跟。
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