用于变应原特异性免疫疗法的基于甘草酸的药物递送系统的制备与表征

Preparation and Characterization of a Glycyrrhizic Acid-Based Drug Delivery System for Allergen-Specific Immunotherapy.

作者信息

Pashkina Ekaterina, Evseenko Veronika, Dumchenko Natalya, Zelikman Maxim, Aktanova Alina, Bykova Maria, Khvostov Mikhail, Dushkin Aleksandr, Kozlov Vladimir

机构信息

Research Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya, 6300099 Novosibirsk, Russia.

Institute of Solid State Chemistry and Mechanochemistry, 18, Kutateladze, 630090 Novosibirsk, Russia.

出版信息

Nanomaterials (Basel). 2021 Dec 31;12(1):148. doi: 10.3390/nano12010148.

DOI:10.3390/nano12010148

PMID:35010098

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8746317/

Abstract

The most effective method of treating allergic diseases, aimed not at relieving symptoms, but at eliminating the cause of the disease, is allergen-specific immunotherapy (AIT). To reduce the risk of side effects and improve the delivery of allergens to the mucosa, various delivery systems, such as liposomes, dendrimers, nanoparticles, etc., can be used. To date, there are data on the creation of delivery systems based on glycyrrhizic acid (GA) and its derivatives, but such a delivery system has not been used for allergen-specific therapy until now. It is also known that GA has an anti-inflammatory effect, shifts the balance towards Th1, and increases the number of Treg cells, meaning that it could potentially enhance the anti-allergic effect of AIT and reduce the risk of unwanted side effects. Thus, the study of the immunomodulatory effect of the supramolecular complexes (micelles) of GA with extracts of allergens holds promise for the development of new drugs for AIT.

摘要

治疗过敏性疾病最有效的方法是变应原特异性免疫疗法（AIT），其目的不是缓解症状，而是消除疾病的病因。为降低副作用风险并改善变应原向黏膜的递送，可使用各种递送系统，如脂质体、树枝状大分子、纳米颗粒等。迄今为止，已有基于甘草酸（GA）及其衍生物创建递送系统的数据，但这种递送系统迄今尚未用于变应原特异性治疗。还已知GA具有抗炎作用，使平衡向Th1偏移，并增加调节性T细胞的数量，这意味着它可能会增强AIT的抗过敏作用并降低不良副作用的风险。因此，研究GA与变应原提取物的超分子复合物（胶束）的免疫调节作用有望开发出用于AIT的新药。