School of Chemical Sciences, Dublin City University, Glasnevin, D09 E432 Dublin, Ireland.
Molecules. 2021 Dec 22;27(1):48. doi: 10.3390/molecules27010048.
Hyaluronic acid (HA) has been implemented for chemo and photothermal therapy to target tumour cells overexpressing the CD44 receptor. HA-targeting hybrid systems allows carbon nanomaterial (CNM) carriers to efficiently deliver anticancer drugs, such as doxorubicin and gemcitabine, to the tumour sites. Carbon nanotubes (CNTs), graphene, graphene oxide (GO), and graphene quantum dots (GQDs) are grouped for a detailed review of the novel nanocomposites for cancer therapy. Some CNMs proved to be more successful than others in terms of stability and effectiveness at removing relative tumour volume. While the literature has been focused primarily on the CNTs and GO, other CNMs such as carbon nano-onions (CNOs) proved quite promising for targeted drug delivery using HA. Near-infrared laser photoablation is also reviewed as a primary method of cancer therapy-it can be used alone or in conjunction with chemotherapy to achieve promising chemo-photothermal therapy protocols. This review aims to give a background into HA and why it is a successful cancer-targeting component of current CNM-based drug delivery systems.
透明质酸（HA）已被应用于化疗和光热治疗，以靶向过度表达 CD44 受体的肿瘤细胞。HA 靶向杂化系统允许碳纳米材料（CNM）载体将阿霉素和吉西他滨等抗癌药物有效地递送到肿瘤部位。碳纳米管（CNTs）、石墨烯、氧化石墨烯（GO）和石墨烯量子点（GQDs）被分组进行详细的综述，以了解用于癌症治疗的新型纳米复合材料。在稳定性和去除相对肿瘤体积的效果方面，一些 CNM 比其他 CNM 更成功。尽管文献主要集中在 CNTs 和 GO 上，但其他 CNM，如碳纳米洋葱（CNOs），在使用 HA 进行靶向药物输送方面表现出相当大的潜力。近红外激光光烧蚀也被综述为一种主要的癌症治疗方法——它可以单独使用或与化疗联合使用，以实现有前途的化疗-光热治疗方案。本综述旨在介绍 HA 及其为何成为当前基于 CNM 的药物输送系统中成功的癌症靶向成分的背景。
