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逆转座子在衰老体组织中的下调和上调。

Retrotransposons Down- and Up-Regulation in Aging Somatic Tissues.

机构信息

Dipartimento di Farmacia e Biotecnologie, Alma Mater Studiorum Università di Bologna, 40126 Bologna, Italy.

CNR Institute of Molecular Genetics "Luigi-Luca Cavalli-Sforza" Unit of Bologna, 40136 Bologna, Italy.

出版信息

Cells. 2021 Dec 28;11(1):79. doi: 10.3390/cells11010079.

DOI:10.3390/cells11010079
PMID:35011640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8750722/
Abstract

The transposon theory of aging hypothesizes the activation of transposable elements (TEs) in somatic tissues with age, leading to a shortening of the lifespan. It is thought that TE activation in aging produces an increase in DNA double-strand breaks, contributing to genome instability and promoting the activation of inflammatory responses. To investigate how TE regulation changes in somatic tissues during aging, we analyzed the expression of some TEs, as well as a source of small RNAs that specifically silence the analyzed TEs; the cluster named . We found significant variations in the expression levels of all the analyzed TEs during aging, with a trend toward reduction in middle-aged adults and reactivation in older individuals that suggests dynamic regulation during the lifespan.

摘要

衰老的转座子理论假设随着年龄的增长，转座元件（TEs）在体组织中被激活，从而导致寿命缩短。人们认为，衰老过程中 TE 的激活会导致 DNA 双链断裂增加，从而导致基因组不稳定，并促进炎症反应的激活。为了研究 TE 在衰老过程中在体组织中的调控变化，我们分析了一些 TE 的表达情况，以及一种专门沉默分析 TE 的小 RNA 的来源；这个簇被命名为 。我们发现，所有分析的 TE 在衰老过程中的表达水平都有显著变化，中年时呈下降趋势，老年时重新激活，表明在整个寿命过程中存在动态调控。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731a/8750722/a3d4512bd102/cells-11-00079-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731a/8750722/ad6ad2e8719f/cells-11-00079-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731a/8750722/0f535a5ab71a/cells-11-00079-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731a/8750722/a3d4512bd102/cells-11-00079-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731a/8750722/ad6ad2e8719f/cells-11-00079-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731a/8750722/0f535a5ab71a/cells-11-00079-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731a/8750722/a3d4512bd102/cells-11-00079-g003.jpg

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The role of transposable elements activity in aging and their possible involvement in laminopathic diseases.转座元件活性在衰老中的作用及其在核纤层蛋白病中的可能参与。
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Transposable Elements, Inflammation, and Neurological Disease.转座元件、炎症与神经疾病
体细胞结构变异的产生是人类肺成纤维细胞衰老的一个标志。
Front Cell Dev Biol. 2023 Dec 13;11:1274807. doi: 10.3389/fcell.2023.1274807. eCollection 2023.
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Elife. 2022 Aug 18;11:e80169. doi: 10.7554/eLife.80169.
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Transposable Elements: Major Players in Shaping Genomic and Evolutionary Patterns.转座元件：塑造基因组和进化模式的主要参与者。
Cells. 2022 Mar 19;11(6):1048. doi: 10.3390/cells11061048.
Front Neurol. 2019 Aug 20;10:894. doi: 10.3389/fneur.2019.00894. eCollection 2019.
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Trapping a somatic endogenous retrovirus into a germline piRNA cluster immunizes the germline against further invasion.将一个体内生源性逆转录病毒捕获到一个种系 piRNA 簇中可使种系免受进一步的入侵。
Genome Biol. 2019 Jun 21;20(1):127. doi: 10.1186/s13059-019-1736-x.
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LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation.衰老野生型和 SIRT6 缺陷小鼠中的去抑制驱动炎症。
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6
Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila.染色质修饰基因干预可抑制果蝇中与衰老相关的转座元件激活并延长其寿命。
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7
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Genetics. 2016 Oct;204(2):631-644. doi: 10.1534/genetics.116.187922. Epub 2016 Aug 24.
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