Park Shin Young, Lee Sang Pyung, Kim Woo Jin
Department of Clinical Laboratory Science, Cheju Halla University, 38 Halladaehak-ro, Jeju-si 63092, Korea.
Brain-Neuro Center, Department of Neurosurgery, Cheju Halla General Hospital, 65 Doryeong-ro, Jeju-si 63127, Korea.
J Clin Med. 2021 Dec 29;11(1):159. doi: 10.3390/jcm11010159.
While there have been major advances in unveiling the mechanisms comprising the ischemic cascade of CNS, stroke continues to be a significant burden. There is a need to extend the focus toward peripheral changes, and the brain-gut axis has recently gained much attention. Our study aimed to evaluate gut inflammation and its association with blood variables in stroke using fecal calprotectin (FC).
Fecal samples were obtained from 27 stroke patients and 27 control subjects. FC was quantitatively measured using a commercial ELISA. Laboratory data on the fecal sample collection were also collected, including CBC, ESR, glucose, creatinine, total protein, albumin, transaminases, and CRP.
There was a significant increase in FC levels in stroke patients compared to the controls. Furthermore, FC in stroke patients was negatively correlated with the Glasgow Coma Scale. Moreover, FC in stroke patients was positively correlated with CRP and negatively correlated with lymphocyte count and albumin.
Our findings show that increased FC is associated with consciousness and systemic response in stroke and warrants further studies to elucidate the usefulness of FC in the management of stroke.
虽然在揭示构成中枢神经系统缺血级联反应的机制方面取得了重大进展，但中风仍然是一个重大负担。有必要将重点扩展到外周变化，而脑-肠轴最近受到了广泛关注。我们的研究旨在使用粪便钙卫蛋白（FC）评估中风患者的肠道炎症及其与血液变量的关联。
从27名中风患者和27名对照受试者中获取粪便样本。使用商业酶联免疫吸附测定法对FC进行定量测量。还收集了粪便样本采集时的实验室数据，包括全血细胞计数、红细胞沉降率、葡萄糖、肌酐、总蛋白、白蛋白、转氨酶和C反应蛋白。
与对照组相比，中风患者的FC水平显著升高。此外，中风患者的FC与格拉斯哥昏迷量表呈负相关。此外，中风患者的FC与C反应蛋白呈正相关，与淋巴细胞计数和白蛋白呈负相关。
我们的研究结果表明，FC升高与中风患者的意识和全身反应相关，值得进一步研究以阐明FC在中风管理中的作用。
