Mizuno Yu, Hirooka Kazuyuki, Kiuchi Yoshiaki
Department of Ophthalmology and Visual Science, Hiroshima University, 1-2-3 Kasumi Minamiku, Hiroshima 734-8551, Japan.
J Clin Med. 2021 Dec 29;11(1):177. doi: 10.3390/jcm11010177.
Recent advances in ocular aberrometry have revealed that ocular surgery increases ocular and corneal higher-order aberrations. This retrospective single-center study aimed to examine the effects of the overhanging bleb on corneal higher-order aberrations using a wavefront analyzer. We included 61 eyes from 50 patients with overhanging bleb after trabeculectomy with a fornix-based conjunctival flap using mitomycin C (overhanging bleb group) and 65 eyes from 54 glaucoma patients with no history of glaucoma surgery (control group). Corneal higher-order aberrations (total higher-order aberrations, coma aberrations, coma-like aberrations, spherical aberrations, and spherical-like aberrations) on a 4 mm pupil diameter were measured using the TOPCON KR-1W wavefront analyzer. Corneal coma aberrations were higher in the overhanging bleb group than in the control group (0.16 ± 0.13 μm and 0.10 ± 0.05 μm, respectively; = 0.042). Corneal coma-like aberrations were also higher in the overhanging bleb group than in the control group (0.31 ± 0.32 μm and 0.16 ± 0.09 μm, respectively; = 0.022). With an increasing ratio of cornea covered by the bleb to the entire cornea, all corneal higher-order aberrations increased except for corneal coma-like aberrations. Overhanging bleb after trabeculectomy with a fornix-based conjunctival flap using mitomycin C and its size influenced corneal higher-order aberrations.
眼像差测量技术的最新进展表明，眼科手术会增加眼和角膜的高阶像差。这项回顾性单中心研究旨在使用波前分析仪检查结膜瓣下滤过泡对角膜高阶像差的影响。我们纳入了50例使用丝裂霉素C行以穹窿为基底的结膜瓣小梁切除术后出现结膜瓣下滤过泡的患者的61只眼（结膜瓣下滤过泡组）和54例无青光眼手术史的青光眼患者的65只眼（对照组）。使用TOPCON KR-1W波前分析仪测量4mm瞳孔直径下的角膜高阶像差（总高阶像差、彗差、类彗差、球差和类球差）。结膜瓣下滤过泡组的角膜彗差高于对照组（分别为0.16±0.13μm和0.10±0.05μm；P = 0.042）。结膜瓣下滤过泡组的角膜类彗差也高于对照组（分别为0.31±0.32μm和0.16±0.09μm；P = 0.022）。随着滤过泡覆盖角膜面积与整个角膜面积之比的增加，除角膜类彗差外，所有角膜高阶像差均增加。使用丝裂霉素C行以穹窿为基底的结膜瓣小梁切除术后的结膜瓣下滤过泡及其大小会影响角膜高阶像差。
