Boyesen Erika Olivia, Balsby Ida Maria, Henriksen Marius, Christensen Robin, Rasmussen Jens Henning, Nielsen Finn Erland, Nygaard Hanne, Friis-Hansen Lennart Jan, Nielsen Susanne Dam, Thudium Rebekka Faber, Porsberg Celeste, Kristensen Lars Erik, Bliddal Henning
The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Copenhagen, Denmark.
Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, 5000 Odense, Denmark.
J Clin Med. 2021 Dec 30;11(1):201. doi: 10.3390/jcm11010201.
C-reactive protein (CRP) has prognostic value in hospitalized patients with COVID-19; the importance of CRP in pre-hospitalized patients remains to be tested. : Individuals with symptoms of COVID-19 had a SARS-CoV-2 PCR oropharyngeal swab test, and a measurement of CRP was performed at baseline, with an upper reference range of 10 mg/L. After 28 days, information about possible admissions, oxygen treatments, transfers to the ICU, or deaths was obtained from the patient files. Using logistic regression, the prognostic value of the CRP and SARS-CoV-2 test results was evaluated. : Among the 1006 patients included, the SARS-CoV-2 PCR test was positive in 59, and the CRP level was elevated (>10 mg/L) in 131. In total, 59 patients were hospitalized, only 3 of whom were SARS-CoV-2 positive, with elevated CRP (n = 2) and normal CRP (n = 1). The probability of being hospitalized with elevated CRP was 4.21 (95%CI 2.38-7.43, < 0.0001), while the probability of being hospitalized with SARS-CoV-2 positivity alone was 0.85 (95%CI 0.26-2.81, = 0.79). : CRP is not a reliable predictor for the course of SARS-CoV-2 infection in pre-hospitalized patients. CRP, while not a SARS-CoV-2 positive test, had prognostic value in the total population of patients presenting with COVID-19-related symptoms.
C反应蛋白（CRP）对COVID-19住院患者具有预后价值；CRP在院前患者中的重要性仍有待验证。有COVID-19症状的个体进行了SARS-CoV-2聚合酶链反应（PCR）口咽拭子检测，并在基线时测量了CRP，其参考范围上限为10mg/L。28天后，从患者档案中获取了有关可能入院、氧疗、转入重症监护病房（ICU）或死亡的信息。使用逻辑回归评估CRP和SARS-CoV-2检测结果的预后价值。在纳入的1006例患者中，59例SARS-CoV-2 PCR检测呈阳性，131例CRP水平升高（>10mg/L）。共有59例患者住院，其中只有3例SARS-CoV-2呈阳性，CRP升高的有2例（n = 2），CRP正常的有1例（n = 1）。CRP升高时住院的概率为4.21（95%置信区间2.38 - 7.43，P<0.0001），而仅SARS-CoV-2呈阳性时住院的概率为0.85（95%置信区间0.26 - 2.81，P = 0.79）。CRP不是院前患者SARS-CoV-2感染病程的可靠预测指标。CRP虽然不是SARS-CoV-2阳性检测指标，但对出现COVID-19相关症状的患者总体具有预后价值。
