Tomczyk-Warunek Agnieszka, Blicharski Tomasz, Muszyński Siemowit, Tomaszewska Ewa, Dobrowolski Piotr, Blicharski Rudolf, Jarecki Jaromir, Arczewska-Włosek Anna, Świątkiewicz Sylwester, Józefiak Damian
Chair and Department of Rehabilitation and Orthopaedics, Medical University in Lublin, 20-090 Lublin, Poland.
Department of Biophysics, University of Life Sciences in Lublin, 20-950 Lublin, Poland.
J Clin Med. 2021 Dec 30;11(1):205. doi: 10.3390/jcm11010205.
There is no information regarding whether changes in the microbiological balance of the gastrointestinal tract as a result of an infection with influence the development of metabolic bone disorders. The experiment was carried out on male broiler chickens divided into two groups: control ( = 10) and experimental ( = 10). The experimental animals were infected with between 17 and 20 days of age. The animals were euthanized at 42 days of age. The structural parameters of the trabecular bone, cortical bone, and hyaline cartilage as well as the mineralization of the bone were determined. The metabolism of the skeletal system was assessed by determining the levels of bone turnover markers, hormones, and minerals in the blood serum. The results confirm that the disturbed composition of the gastrointestinal microflora has an impact on the mineralization and metabolism of bone tissue, leading to the structural changes in cortical bone, trabecular bone, and hyaline cartilage. On the basis of the obtained results, it can be concluded that changes in the microenvironment of the gastrointestinal tract by infection with may have an impact on the earlier development of osteoporosis.
关于因感染 导致的胃肠道微生物平衡变化是否会影响代谢性骨病的发展，目前尚无相关信息。实验在雄性肉鸡上进行，将其分为两组：对照组（ = 10）和实验组（ = 10）。实验组动物在17至20日龄时感染 。动物在42日龄时安乐死。测定了松质骨、皮质骨和透明软骨的结构参数以及骨矿化情况。通过测定血清中骨转换标志物、激素和矿物质的水平来评估骨骼系统的代谢。结果证实，胃肠道微生物群组成的紊乱会影响骨组织的矿化和代谢，导致皮质骨、松质骨和透明软骨的结构变化。根据所得结果可以得出结论，感染 导致的胃肠道微环境变化可能会对骨质疏松症的早期发展产生影响。
