Tomaszewska Ewa, Dobrowolski Piotr, Muszyński Siemowit, Kostro Krzysztof, Taszkun Iwona, Żmuda Andrzej, Blicharski Tomasz, Hułas-Stasiak Monika
Department of Animal Physiology, 20-950 Lublin, Poland.
Department of Comparative Anatomy and Anthropology, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Lublin, 20-033 Poland.
J Vet Res. 2017 Sep 19;61(3):357-362. doi: 10.1515/jvetres-2017-0047. eCollection 2017 Sep.
The aim of the study was to investigate the mechanical and geometric properties as well as bone tissue and mineral density of long bones in mink dams exposed to deoxynivalenol (DON) since one day after mating, throughout gestation (ca. 46 d) and lactation to pelt harvesting.
Thirty clinically healthy multiparous minks () of the standard dark brown type were used. After the mating, the minks were randomly assigned into two equal groups: non-treated control group and DON group fed wheat contaminated naturally with DON at a concentration of 1.1 mg·kg of feed.
The final body weight and weight and length of the femur did not differ between the groups. However, DON contamination decreased mechanical endurance of the femur. Furthermore, DON reduced the mean relative wall thickness and vertical wall thickness of the femur, while vertical cortical index, midshaft volume, and cross-sectional moment of inertia increased. Finally, DON contamination did not alter bone tissue density, bone mineral density, or bone mineral content, but decreased the values of all investigated structural and material properties.
DON at applied concentration probably intensified the process of endosteal resorption, which was the main reason for bone wall thinning and the weakening of the whole bone.
本研究的目的是调查自交配后一天起，在整个妊娠期（约46天）和哺乳期直至取皮期间，暴露于脱氧雪腐镰刀菌烯醇（DON）的水貂母兽长骨的力学和几何特性以及骨组织和矿物质密度。
使用30只临床健康的标准深褐色多胎水貂（）。交配后，将水貂随机分为两组：未处理的对照组和DON组，DON组饲喂天然被DON污染、浓度为1.1毫克·千克饲料的小麦。
两组之间的最终体重以及股骨的重量和长度没有差异。然而，DON污染降低了股骨的机械耐力。此外，DON降低了股骨的平均相对壁厚和垂直壁厚，而垂直皮质指数、骨干体积和截面惯性矩增加。最后，DON污染没有改变骨组织密度、骨矿物质密度或骨矿物质含量，但降低了所有研究的结构和材料特性的值。
所应用浓度的DON可能加剧了骨内膜吸收过程，这是骨壁变薄和整个骨骼变弱的主要原因。
