Verwaest C, Demeyere R, Ferdinande P, Schetz M, Van Damme K, Lauwers P
Department of Anesthesiology, University Hospital Gasthuisberg, Leuven, Belgium.
Acta Anaesthesiol Belg. 1987;38(3 Suppl 1):9-16.
The new water-soluble benzodiazepine midazolam was compared in a randomized study to diazepam for postoperative sedation in fifty patients following aortocoronary bypass surgery with a sufentanil-anesthesia. Midazolam and diazepam were administered intravenously in repeated doses in conjunction with an opioid infusion (piritramide) from the end of surgery during a twelve-hour study period, patients being artificially ventilated. Midazolam scored better than diazepam for quality of sedation and cardiovascular stability during the period of mechanical ventilation and for respiration during the weaning period and after extubation, although no difference was found in weaning time from artificial ventilation and time of extubation. Hemodynamic tolerance for both drugs was good. The administration of a loading dose of midazolam 5 mg caused a slight, transient decrease in mean arterial pressure. Midazolam appeared to be a more effective sedative agent than diazepam for short-term administration during mechanical ventilation. No evidence of cumulation and prolonged recovery was seen.
在一项随机研究中，将新型水溶性苯二氮䓬类药物咪达唑仑与地西泮用于50例接受舒芬太尼麻醉的主动脉冠状动脉搭桥手术后患者的术后镇静进行了比较。在为期12小时的研究期间，从手术结束开始，咪达唑仑和地西泮与阿片类药物输注（匹利卡明）一起静脉重复给药，患者进行人工通气。在机械通气期间的镇静质量和心血管稳定性以及撤机期间和拔管后的呼吸方面，咪达唑仑的评分优于地西泮，尽管在人工通气撤机时间和拔管时间上未发现差异。两种药物的血流动力学耐受性良好。给予5mg负荷剂量的咪达唑仑会导致平均动脉压轻微、短暂下降。在机械通气期间短期给药时，咪达唑仑似乎是比地西泮更有效的镇静剂。未观察到蓄积和恢复延长的迹象。
