Kremer M J, Bachenberg K L
AANA J. 1993 Jun;61(3):273-6.
The problem of sedation and analgesia for ventilator-dependent patients was examined in this study. Twenty subjects undergoing elective coronary revascularization surgery at a major medical center were studied. They ranged in age from 49 to 83 years. A randomized, prospective research design was used to place subjects in either an experimental group or a control group. Standard postoperative analgesia with intravenous increments of morphine and midazolam in the control group was compared to treatment with a titratable sufentanil-midazolam infusion in the experimental group. In both groups, hemodynamic variables were measured at selected intervals, sodium nitroprusside consumption was measured, and time to extubation was noted. Data analysis demonstrated no statistically significant differences between the experimental and control groups. The more costly sedative-analgesic infusion appeared to be comparable to conventional treatment with incremental morphine and midazolam based on the results of this study.
本研究探讨了依赖呼吸机患者的镇静和镇痛问题。对一家大型医疗中心20名接受择期冠状动脉血运重建手术的受试者进行了研究。他们的年龄在49岁至83岁之间。采用随机、前瞻性研究设计将受试者分为实验组或对照组。对照组采用静脉递增吗啡和咪达唑仑进行标准术后镇痛，实验组采用可滴定的舒芬太尼-咪达唑仑输注治疗。在两组中，在选定的时间间隔测量血流动力学变量，测量硝普钠的消耗量，并记录拔管时间。数据分析表明，实验组和对照组之间没有统计学上的显著差异。根据本研究结果，成本更高的镇静镇痛输注似乎与递增吗啡和咪达唑仑的传统治疗相当。
