Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského nám. 2, 162 00 Prague 6, Czechia.
Department of Medical Microbiology, Second Faculty of Medicine, Charles University and Motol University Hospital, V Úvalu 84, 150 06 Prague 5, Czechia.
Nanomedicine (Lond). 2022 Feb;17(3):137-149. doi: 10.2217/nnm-2021-0323. Epub 2022 Jan 11.
Antimicrobial submicrometer particles are being studied as promising interventions against a wide range of skin conditions, such as fungal or bacterial infections. To submicronize chloroxine, the crystalline compound 5,7-dichloro-8-hydroxyquinoline, by nanoprecipitation and characterize the resulting assemblies. The chloroxine particles were stabilized by a nonionic surfactant and were studied by a broth microdilution assay against 20 medically important bacteria and fungi. The intervention was studied using a murine model of skin irritation. Chloroxine nanoparticles with a diameter of 600-800 nm exhibit good tolerability in terms of skin irritation and good antimicrobial activity. Thus, the fabricated formulation shows great promise for interventions for both cutaneous infection control and prophylaxis.
抗菌亚微米颗粒作为一种有前途的治疗方法，正在被研究用于治疗各种皮肤疾病，如真菌感染或细菌感染。为了对氯氧喹啉（5,7-二氯-8-羟基喹啉）进行亚微米化处理，通过纳米沉淀的方法对结晶化合物进行处理，并对得到的组装体进行了表征。氯氧喹啉颗粒由非离子表面活性剂稳定，并通过肉汤微量稀释法对 20 种重要的医学细菌和真菌进行了检测。采用皮肤刺激的小鼠模型对该干预措施进行了研究。直径为 600-800nm 的氯氧喹啉纳米颗粒在皮肤刺激性方面表现出良好的耐受性和良好的抗菌活性。因此，所制备的配方在控制和预防皮肤感染方面具有广阔的应用前景。
