三叉辐射状结构表明，Xq27处脆性位点的表达是无致死性的。
Triradial configurations indicate that expression of the fragile site at Xq27 is non-lethal.
作者信息
Tommerup N
机构信息
Dept. of Medical Genetics, John F. Kennedy Institute, Glostrup, Denmark.
出版信息
Ann Genet. 1987;30(4):231-2.
PMID:3501266
Abstract
The staining pattern of BUdR-substituted sister chromatids in triradial configurations associated with the fragile site at Xq27 is reported. The pattern observed in 2nd- and 3rd-generation cells is compatible with the hypothesis that the triradial configurations are caused by mitotic non-disjunction of the distal fragment in the previous mitotic division. This in turn indicates that cells can survive expression of the fragile site in a previous cell cycle.
摘要
报道了与Xq27脆性位点相关的三射体构型中溴脱氧尿苷（BUdR）取代的姐妹染色单体的染色模式。在第二代和第三代细胞中观察到的模式与以下假设相符：三射体构型是由前一次有丝分裂中远端片段的有丝分裂不分离引起的。这进而表明细胞能够在先前细胞周期中脆性位点表达的情况下存活。
相似文献
1
2
Implications of fragile X expression in normal males for the nature of the mutation.正常男性中脆性X表达对突变性质的影响。
Nature. 1986;324(6093):161-3. doi: 10.1038/324161a0.
3
Increased sister chromatid exchange frequency at Xq27 site in affected fragile X males.
Am J Med Genet. 1987 Apr;26(4):909-14. doi: 10.1002/ajmg.1320260419.
4
Frequency of tri- or multiradial configurations in fragile X identification.脆性X染色体鉴定中三射或多射构型的频率
Am J Med Genet. 1986 Jan-Feb;23(1-2):531-5. doi: 10.1002/ajmg.1320230145.
5
[Recombination between the fragile site Xq27 and the gene for coagulation factor IX].
Ann Genet. 1985;28(4):201-5.
6
7
Concurrence of the triple-X syndrome and expression of the fragile site Xq27.3.三X综合征与脆性位点Xq27.3的并发。
Hum Genet. 1988 Mar;78(3):293. doi: 10.1007/BF00291682.
8
[Mental retardation linked to fragility of chromosome X: current knowledge].
J Genet Hum. 1984 Jul;32(3):167-92.
9
A premutation that generates a defect at crossing over explains the inheritance of fragile X mental retardation.
Am J Med Genet. 1985 Aug;21(4):709-17. doi: 10.1002/ajmg.1320210413.
10
Replication status of fragile X(q27.3) in 13 female heterozygotes.13名女性杂合子中脆性X（q27.3）的复制状态。
J Med Genet. 1986 Oct;23(5):407-10. doi: 10.1136/jmg.23.5.407.
Zotero 插件