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Increased sister chromatid exchange frequency at Xq27 site in affected fragile X males.

作者信息

Wenger S L, Hennessey J C, Steele M W

出版信息

Am J Med Genet. 1987 Apr;26(4):909-14. doi: 10.1002/ajmg.1320260419.

DOI:10.1002/ajmg.1320260419
PMID:3591833
Abstract

Sister chromatid exchange (SCE) was evaluated in peripheral blood lymphocytes cultured from normal subjects, fragile X carrier females, and fragile X affected males and in general did not differ among all subjects whether cells were grown in thymidine-deficient or complete medium. However, at the Xq27 site, SCE was significantly increased for fragile X affected males, particularly in cells grown in thymidine-deficient medium.

摘要

相似文献

1
Increased sister chromatid exchange frequency at Xq27 site in affected fragile X males.
Am J Med Genet. 1987 Apr;26(4):909-14. doi: 10.1002/ajmg.1320260419.
2
Implications of fragile X expression in normal males for the nature of the mutation.正常男性中脆性X表达对突变性质的影响。
Nature. 1986;324(6093):161-3. doi: 10.1038/324161a0.
3
[Spontaneous and induced chromosome instability in patients with fragile X syndrome].[脆性X综合征患者的自发和诱导染色体不稳定性]
Genetika. 1987 Mar;23(3):504-9.
4
Folate metabolism in cells from fragile X syndrome patients and carriers.脆性X综合征患者及携带者细胞中的叶酸代谢
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5
Antifolate-induced misincorporation of deoxyuridine monophosphate into DNA by cells from patients with the fragile X syndrome.抗叶酸诱导脆性X综合征患者细胞将单磷酸脱氧尿苷错误掺入DNA。
Am J Med Genet. 1985 Aug;21(4):691-6. doi: 10.1002/ajmg.1320210410.
6
Triradial configurations indicate that expression of the fragile site at Xq27 is non-lethal.三叉辐射状结构表明，Xq27处脆性位点的表达是无致死性的。
Ann Genet. 1987;30(4):231-2.
7
The fragile X syndrome I: familial variation in the proportion of lymphocytes with the fragile site in males.脆性X综合征I：男性淋巴细胞中具有脆性位点的比例的家族性差异。
Am J Med Genet. 1984 Jan;17(1):241-52. doi: 10.1002/ajmg.1320170115.
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Induction of the fragile X on BrdU-substituted chromosomes with direct visualization of sister chromatid exchanges on banded chromosomes.在经BrdU替代的染色体上诱导脆性X，同时在显带染色体上直接观察姐妹染色单体交换。
Hum Genet. 1989 Mar;81(4):377-81. doi: 10.1007/BF00283696.
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The fragile X syndrome (Martin-Bell syndrome). Clinical and cytogenetic findings in 16 prepubertal boys and in 4 of their 5 families.脆性X综合征（马丁-贝尔综合征）。16名青春期前男孩及其5个家庭中4个家庭的临床和细胞遗传学发现。
Helv Paediatr Acta. 1985 Jul;40(2-3):133-52.
10
The fragile X(q27) form of X-linked mental retardation: FUdR as an inducing agent for fra(X)(q27) expression in lymphocytes, fibroblasts, and amniocytes.
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引用本文的文献

1
repeat expansion creates the unstable folate-sensitive fragile site FRA9A.重复扩增产生不稳定的叶酸敏感脆性位点FRA9A。
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2
Fragile sites, chromosomal lesions, tandem repeats, and disease.脆性位点、染色体病变、串联重复序列与疾病。
Front Genet. 2022 Nov 17;13:985975. doi: 10.3389/fgene.2022.985975. eCollection 2022.
3
Induction of sister chromatid exchanges at common fragile sites.
Am J Hum Genet. 1987 Nov;41(5):882-90.
4
Induction of the fragile X on BrdU-substituted chromosomes with direct visualization of sister chromatid exchanges on banded chromosomes.在经BrdU替代的染色体上诱导脆性X，同时在显带染色体上直接观察姐妹染色单体交换。
Hum Genet. 1989 Mar;81(4):377-81. doi: 10.1007/BF00283696.
5
Increased frequencies of sister chromatid exchanges at common fragile sites (1)(q42) and (19)(q13).
Hum Genet. 1989 Sep;83(2):145-7. doi: 10.1007/BF00286707.
6
"Spontaneous" FRA16B is a hot spot for sister chromatid exchanges.“自发的”FRA16B是姐妹染色单体交换的热点区域。
Hum Genet. 1991 Sep;87(5):583-6. doi: 10.1007/BF00209017.
7
Sister chromatid exchanges are preferentially induced at expressed and nonexpressed common fragile sites.姐妹染色单体交换优先在表达和未表达的常见脆性位点诱导产生。
Hum Genet. 1991 Jul;87(3):302-6. doi: 10.1007/BF00200908.
8
Induction of distamycin A-inducible rare fragile sites and increased sister chromatid exchanges at the fragile site.放线菌素A诱导稀有脆性位点的产生以及脆性位点处姐妹染色单体交换增加。
Hum Genet. 1991 Jul;87(3):254-60. doi: 10.1007/BF00200900.
9
Differential bleomycin susceptibility in cultured lymphocytes of fragile X patients and normal individuals.脆性X患者与正常个体培养淋巴细胞中博来霉素敏感性差异
Hum Genet. 1990 Aug;85(3):267-71. doi: 10.1007/BF00206743.