Istituto dei Materiali per l'Elettronica e il Magnetismo (IMEM), National Research Council CNR, Parco Area delle Scienze 37/A, 43124, Parma, IT, Italy.
Istituto di Scienze e Tecnologie Chimiche "Giulio Natta", Consiglio Nazionale delle Ricerche (SCITEC-CNR), Via A. Corti 12, 20133, Milan, IT, Italy.
Nat Commun. 2022 Jan 10;13(1):6. doi: 10.1038/s41467-021-27637-2.
Myocardial infarction causes 7.3 million deaths worldwide, mostly for fibrillation that electrically originates from the damaged areas of the left ventricle. Conventional cardiac bypass graft and percutaneous coronary interventions allow reperfusion of the downstream tissue but do not counteract the bioelectrical alteration originated from the infarct area. Genetic, cellular, and tissue engineering therapies are promising avenues but require days/months for permitting proper functional tissue regeneration. Here we engineered biocompatible silicon carbide semiconductive nanowires that synthetically couple, via membrane nanobridge formations, isolated beating cardiomyocytes over distance, restoring physiological cell-cell conductance, thereby permitting the synchronization of bioelectrical activity in otherwise uncoupled cells. Local in-situ multiple injections of nanowires in the left ventricular infarcted regions allow rapid reinstatement of impulse propagation across damaged areas and recover electrogram parameters and conduction velocity. Here we propose this nanomedical intervention as a strategy for reducing ventricular arrhythmia after acute myocardial infarction.
心肌梗死导致全球 730 万人死亡，其中大多数是由左心室受损区域引发的电颤动导致的。传统的心脏旁路移植和经皮冠状动脉介入治疗可以使下游组织再灌注，但不能逆转梗死区域产生的生物电变化。基因、细胞和组织工程治疗是很有前途的途径，但需要数天/数月才能允许适当的功能性组织再生。在这里，我们设计了生物相容性的碳化硅半导体纳米线，通过膜纳米桥的形成，将分离的跳动心肌细胞远距离连接起来，恢复生理细胞间的电导，从而使原本不耦合的细胞的生物电活动同步。在左心室梗死区域的局部原位多次注射纳米线，可迅速恢复冲动在受损区域的传播，并恢复电图参数和传导速度。在这里，我们提出这种纳米医学干预作为一种策略，以减少急性心肌梗死后的室性心律失常。
