Centre for Fertility and Health, Norwegian Institute of Public Health, Postboks 4404 Nydalen, 0403, Oslo, Norway.
Columbia University, New York, USA.
Sci Rep. 2022 Jan 10;12(1):402. doi: 10.1038/s41598-021-04195-7.
There is a lack of studies assessing how hearing impairment relates to reproductive outcomes. We examined whether childhood hearing impairment (HI) affects reproductive patterns based on longitudinal Norwegian population level data for birth cohorts 1940-1980. We used Poisson regression to estimate the association between the number of children ever born and HI. The association with childlessness is estimated by a logit model. As a robustness check, we also estimated family fixed effects Poisson and logit models. Hearing was assessed at ages 7, 10 and 13, and reproduction was observed at adult ages until 2014. Air conduction hearing threshold levels were obtained by pure-tone audiometry at eight frequencies from 0.25 to 8 kHz. Fertility data were collected from Norwegian administrative registers. The combined dataset size was N = 50,022. Our analyses reveal that HI in childhood is associated with lower fertility in adulthood, especially for men. The proportion of childless individuals among those with childhood HI was almost twice as large as that of individuals with normal childhood hearing (20.8% vs. 10.7%). The negative association is robust to the inclusion of family fixed effects in the model that allow to control for the unobserved heterogeneity that are shared between siblings, including factors related to the upbringing and parent characteristics. Less family support in later life could add to the health challenges faced by those with HI. More attention should be given to how fertility relates to HI.
目前缺乏评估听力障碍与生殖结果之间关系的研究。我们检验了儿童时期听力障碍(HI)是否会根据 1940-1980 年出生队列的挪威人群水平数据影响生殖模式。我们使用泊松回归估计了生育子女数量与 HI 之间的关联。通过对数模型估计与不孕不育的关系。作为稳健性检查,我们还估计了家庭固定效应泊松和对数模型。听力在 7、10 和 13 岁时进行评估,生育在 2014 年之前在成年人年龄时进行观察。通过纯音测听在 0.25 到 8 kHz 的八个频率上获得空气传导听力阈值。生育数据从挪威行政登记处收集。综合数据集大小为 N=50,022。我们的分析表明,儿童时期的 HI 与成年后较低的生育能力有关,尤其是对男性而言。在患有儿童 HI 的人群中,无子女的比例几乎是听力正常儿童的两倍(20.8%比 10.7%)。该负相关在模型中包含家庭固定效应时是稳健的,这允许控制兄弟姐妹之间共同存在的未观察到的异质性,包括与养育和父母特征有关的因素。晚年家庭支持减少可能会增加 HI 患者面临的健康挑战。应该更加关注生育与 HI 的关系。