Division of Aging and Geriatric Dentistry, Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Miyagi, Japan.
Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan.
Sci Rep. 2022 Jan 10;12(1):440. doi: 10.1038/s41598-021-04158-y.
Globally, the cancer burden is expected to increase as populations are ageing. Therefore, cancer prevention among older age groups is important. This prospective cohort study examined the relationship between the number of remaining teeth, maximum occlusal force, and incidence of gastrointestinal cancer in community-dwelling older Japanese individuals using data from the Tsurugaya project; 847 participants were included. The exposure variables were the number of remaining teeth and the maximum occlusal force, with the outcome being the incidence of gastrointestinal cancer. Covariates were age, sex, medical history, smoking, alcohol consumption, educational attainment, and physical function. The Cox proportional hazard model was used to examine the relationship between the number of remaining teeth, maximum occlusal force, and incidence of gastrointestinal cancer. With a median follow-up of 7.6 years, 63 participants were confirmed to have gastrointestinal cancer. The risk of gastrointestinal cancer was significantly higher in those with an occlusal force lower than the median (hazard ratio, 2.80; 95% confidence interval, 1.54-5.10). No significant risk difference was found according to the number of remaining teeth. Low maximum occlusal force was associated with the incidence of gastrointestinal cancer in community-dwelling older Japanese adults.
全球范围内，随着人口老龄化，癌症负担预计将增加。因此，老年人群体的癌症预防非常重要。本前瞻性队列研究使用 Tsurugaya 项目的数据，在社区居住的日本老年人中，检查了剩余牙齿数量、最大咬合力量与胃肠道癌症发病之间的关系；共纳入 847 名参与者。暴露变量为剩余牙齿数量和最大咬合力量，结局为胃肠道癌症的发病情况。协变量为年龄、性别、既往病史、吸烟、饮酒、受教育程度和身体功能。采用 Cox 比例风险模型来检查剩余牙齿数量、最大咬合力量与胃肠道癌症发病之间的关系。中位随访 7.6 年后，63 名参与者被确诊患有胃肠道癌症。咬合力量低于中位数的患者胃肠道癌症发病风险显著更高（风险比，2.80；95%置信区间，1.54-5.10）。根据剩余牙齿数量，未发现显著的风险差异。最大咬合力量较低与社区居住的日本老年成年人胃肠道癌症的发病有关。
