Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Department of Neonatal Intensive Care, Oslo University Hospital, Ullevål, Oslo, Norway.
Pediatr Res. 2022 Oct;92(4):1132-1139. doi: 10.1038/s41390-021-01915-7. Epub 2022 Jan 10.
Evidence regarding the predictive value of early amplitude-integrated electroencephalography (aEEG)/EEG on neurodevelopmental outcomes at school age and beyond is lacking. We aimed to investigate whether there is an association between early postnatal EEG and neurocognitive outcomes in late childhood.
This study is an observational prospective cohort study of premature infants with a gestational age <28 weeks. The total absolute band powers (tABP) of the delta, theta, alpha, and beta bands were analyzed from EEG recordings during the first three days of life. At 10-12 years of age, neurocognitive outcomes were assessed using the Wechsler Intelligence Scale for Children 4th edition (WISC-IV), Vineland adaptive behavior scales 2nd edition, and Behavior Rating Inventory of Executive Function (BRIEF). The mean differences in tABP were assessed for individuals with normal versus unfavorable neurocognitive scores.
Twenty-two infants were included. tABP values in all four frequency bands were significantly lower in infants with unfavorable results in the main composite scores (full intelligence quotient, adaptive behavior composite score, and global executive composite score) on all three tests (p < 0.05).
Early postnatal EEG has the potential to assist in predicting cognitive outcomes at 10-12 years of age in extremely premature infants <28 weeks' gestation.
Evidence regarding the value of early postnatal EEG in long-term prognostication in preterm infants is limited. Our study suggests that early EEG spectral analysis correlates with neurocognitive outcomes in late childhood in extremely preterm infants. Early identification of infants at-risk of later impairment is important to initiate early and targeted follow-up and intervention.
关于振幅整合脑电图（aEEG）/脑电图在学龄期及以后对神经发育结局的预测价值的证据尚缺乏。我们旨在研究新生儿期后脑电图与儿童晚期神经认知结局之间是否存在关联。
这是一项对胎龄<28 周的早产儿进行的观察性前瞻性队列研究。对生后第 1-3 天的脑电图记录进行分析，得到δ、θ、α和β频段的总绝对频带功率（tABP）。在 10-12 岁时，使用韦氏儿童智力量表第四版（WISC-IV）、韦氏适应行为量表第二版和行为评定量表-执行功能（BRIEF）评估神经认知结局。评估了 tABP 在神经认知评分正常与异常个体之间的差异。
共纳入 22 名婴儿。在所有三种测试中，主要综合评分（全智商、适应行为综合评分和整体执行综合评分）结果异常的婴儿的所有四个频带的 tABP 值均显著降低（p<0.05）。
新生儿期后脑电图可能有助于预测<28 周胎龄的极早产儿 10-12 岁时的认知结局。
关于早产儿出生后脑电图在长期预后中的价值的证据有限。我们的研究表明，早期脑电图频谱分析与极度早产儿儿童晚期的神经认知结局相关。早期识别有后期受损风险的婴儿对于早期和有针对性的随访和干预非常重要。
