Keller G E, Lewis D M, Olenchock S A
Department of Biology, West Virginia University, Morgantown 26506.
Comp Immunol Microbiol Infect Dis. 1987;10(3-4):219-26. doi: 10.1016/0147-9571(87)90032-4.
The inhalation of grain dust by grain workers is responsible for a large number of pulmonary pathophysiologies. These problems may be acute or chronic and may be mediated by the chronic activation of the immune system. Constant inflammatory states in the lung may eventually lead to tissue damage and respiratory deficit. This study was designed to measure the changes in the relative number of inflammatory cells in peripheral blood, bronchoalveolar spaces, and lung interstitium that occur in response to intratracheally instilled airborne spring wheat dust in rats. It was found that 6 h after instillation with dust, neutrophils were present in greater numbers in the blood and bronchoalveolar spaces than in lung interstitium. After 24 h, there appeared to be a larger number of neutrophils in the lung interstitium in dust-instilled animals than in saline-instilled controls. These results indicate that intratracheal instillation of grain dust initiates an acute inflammatory reaction, and that there is an initial influx of neutrophils into the air spaces of the lung followed by transit of these cells into the lung interstitium.
谷物加工工人吸入谷物粉尘会引发大量肺部病理生理问题。这些问题可能是急性的，也可能是慢性的，并且可能由免疫系统的慢性激活介导。肺部持续的炎症状态最终可能导致组织损伤和呼吸功能障碍。本研究旨在测量大鼠气管内注入空气中的春小麦粉尘后，外周血、支气管肺泡腔和肺间质中炎症细胞相对数量的变化。结果发现，注入粉尘6小时后，血液和支气管肺泡腔中的中性粒细胞数量比肺间质中的更多。24小时后，注入粉尘的动物肺间质中的中性粒细胞数量似乎比注入生理盐水的对照组更多。这些结果表明，气管内注入谷物粉尘会引发急性炎症反应，并且最初有中性粒细胞流入肺的气腔，随后这些细胞转移到肺间质。
