White L R, Steinegger A F, Schlatter C
Environ Res. 1987 Apr;42(2):534-45. doi: 10.1016/s0013-9351(87)80220-7.
Rats were examined for lung changes 7 days and 22 weeks after a single intratracheal instillation of potroom dust from an aluminum reduction plant. In the acute study, 0.5 mg potroom dust induced changes at the pulmonary surface, and a 5.0-mg dose caused marked changes both at the pulmonary surface and in lung tissue. By contrast, 5.0 mg virginal alumina caused only a mild increase in the number of polymorphonuclear leukocytes in the lung. In the long-term study, potroom dust, virginal alumina, and DQ12 alpha-quartz were instilled at a dose of 5.0 mg. In the cases of potroom dust and virginal alumina, all parameters measured had returned to control levels after 22 weeks, whereas DQ12 induced a massive inflammation and an accumulation of pulmonary surfactant. It is concluded that this air sample of potroom dust causes marked acute irritation and inflammation in rat lung and that this type of dust may therefore be active in human lung and thus contribute to the acute respiratory symptoms experienced by some potroom workers. However, despite the marked acute toxicity of the comparatively high 5.0-mg dose, rat lung appears to return to normal within 22 weeks with no signs of chronic toxicity from this single instillation.
在单次气管内滴注来自一家铝冶炼厂的电解车间粉尘后，分别于7天和22周对大鼠的肺部变化进行检查。在急性研究中，0.5毫克电解车间粉尘引起肺表面变化，5.0毫克剂量则在肺表面和肺组织均引起显著变化。相比之下，5.0毫克的原始氧化铝仅使肺中多形核白细胞数量轻度增加。在长期研究中，以5.0毫克的剂量滴注电解车间粉尘、原始氧化铝和DQ12 α-石英。对于电解车间粉尘和原始氧化铝，22周后所有测量参数均恢复到对照水平，而DQ12引起大量炎症和肺表面活性物质积聚。得出的结论是，这种电解车间粉尘空气样本会在大鼠肺部引起明显的急性刺激和炎症，因此这种类型的粉尘可能在人类肺部具有活性，从而导致一些电解车间工人出现急性呼吸道症状。然而，尽管相对较高的5.0毫克剂量具有明显的急性毒性，但大鼠肺在22周内似乎恢复正常，单次滴注未出现慢性毒性迹象。
