Department of Internal Medicine, Division of Rheumatology, Facultyof Medicine, Gazi University, 06100, Ankara, Turkey.
Department of Biochemistry, FacultyofMedicine, Gazi University, Ankara, Turkey.
Clin Rheumatol. 2022 Apr;41(4):1169-1176. doi: 10.1007/s10067-021-06020-y. Epub 2022 Jan 11.
The aim of the present study was to investigate serum fetuin-A (Fet-A) levels in patients with Takayasu arteritis (TA) and granulomatous polyangiitis (GPA) and to analyze the relationship between serum Fet-A levels and disease activity scores.
Thirty-two TA and 28 GPA patients presented to the rheumatology clinic at Gazi University and met the criteria of American College of Rheumatology 1990 and 2012 International Chapell Hill meeting, respectively, and 20 healthy control subjects were included in the present study. We collected data on serum C-reactive protein (CRP), albumin, calcium, and phosphate levels as well as erythrocyte sedimentation rates. Calcification risk index (CRI) was calculated for each patient. The Birmingham Vasculitis Activity Score (BVAS) and Indian Takayasu Clinical Activity Score (ITAS), were used to assess disease activity in GPA and TA patients respectively.
Serum Fet-A levels were significantly lower in the overall vasculitis group compared to control group (p = 0.015). In subgroup analysis, Fet-A levels were significantly lower in those with active disease, compared to control group (p = 0.001, for active TA (n = 18) and GPA (n = 17), respectively). However, there was no significant difference in serum Fet-A levels in inactive cases versus control subjects (p = 0.061, for inactive TA (n = 14) and GPA (n = 11), respectively). Serum Fet-A levels negatively correlated with BVAS (r = - 0.675) and ITAS scores (r = - 0.385), as well as with CRP and CRI.
Our results suggest that serum Fet-A level could be a novel biomarker for assessment of activity status in patients with GPA or TA. Key Points • Serum Fetuin-A is negative acute phase protein and systemic calcification inhibitor synthesized in hepatocytes and secreted by various inflammation. • Serum Fetuin-A was negatively correlated with CRP, BVAS, and ITAS scores and significantly decreased in vasculitis patients with high disease activity. • Serum Fetuin-A could be a promising and useful biomarker for the assessment of disease activity for vasculitis, also that it might also be a predictor of long-term cardiovascular progression.
本研究旨在探讨大动脉炎（TA）和肉芽肿性多血管炎（GPA）患者的血清胎球蛋白-A（Fet-A）水平，并分析其与疾病活动评分之间的关系。
本研究纳入了 32 例 TA 患者和 28 例 GPA 患者，他们均在加济大学风湿病门诊就诊，并符合美国风湿病学会 1990 年和 2012 年国际 Chapel Hill 会议的标准，同时纳入了 20 名健康对照者。我们收集了血清 C 反应蛋白（CRP）、白蛋白、钙和磷水平以及红细胞沉降率的数据。为每位患者计算了钙化风险指数（CRI）。采用 Birmingham 血管炎活动评分（BVAS）和印度大动脉炎临床活动评分（ITAS）分别评估 GPA 和 TA 患者的疾病活动度。
总体血管炎组的血清 Fet-A 水平明显低于对照组（p=0.015）。在亚组分析中，与对照组相比，活动期疾病患者的 Fet-A 水平明显降低（分别为活动期 TA（n=18）和 GPA（n=17），p=0.001）。然而，在非活动期病例与对照组之间，血清 Fet-A 水平无显著差异（分别为非活动期 TA（n=14）和 GPA（n=11），p=0.061）。血清 Fet-A 水平与 BVAS（r=-0.675）和 ITAS 评分（r=-0.385）以及 CRP 和 CRI 呈负相关。
我们的研究结果表明，血清 Fet-A 水平可能是评估 GPA 或 TA 患者活动状态的新型生物标志物。关键点：
血清胎球蛋白-A 是一种由肝细胞合成并由各种炎症分泌的负急性相蛋白和系统性钙化抑制剂。
血清 Fetuin-A 与 CRP、BVAS 和 ITAS 评分呈负相关，且在疾病活动度高的血管炎患者中显著降低。
血清 Fetuin-A 可能是评估血管炎疾病活动度的有前途且有用的生物标志物，也可能是长期心血管进展的预测因子。
