Feĭgin A M, Belousova I I, Tereshin I M
Antibiotiki. 1978 May;23(5):411-3.
Characteristics of a mutant of the yeast-like fungus Candida albicans with increased sensitivity to amphotericin B, levorin and nystatin is presented. Increased sensitivity to the polyens in the isolate must be associated with changes in the cell wall and/or with decreased total viability of the strain. The following factors were in favour of this: presence of significant amounts of pseudomycelial cells with thinner cell walls as compared to the yeast cells in the population of the mutant strain; a higher rate of potassium liberation from the cells of the mutant strain in the presence of amphotericin B; a lower growth rate of the mutant strain on solid and liquid media; an increased death rate of the cells in the intact culture of the mutant strain as compared to the initial strain; absence of changes in the absorption spectrum of sterols isolated from the cells of the mutant strain as compared to the initial culture.
本文介绍了一种对两性霉素B、制霉菌素和里沃菌素敏感性增加的白色念珠菌样真菌突变体的特征。该分离株对多烯类药物敏感性增加必定与细胞壁变化和/或菌株总活力降低有关。以下因素支持这一观点：与突变株群体中的酵母细胞相比，存在大量细胞壁较薄的假菌丝细胞；在两性霉素B存在下，突变株细胞释放钾的速率更高；突变株在固体和液体培养基上的生长速率较低；与初始菌株相比，突变株完整培养物中细胞的死亡率增加；与初始培养物相比，从突变株细胞中分离出的固醇的吸收光谱没有变化。
