Özalkak Şervan, Yıldırım Ruken, Tunç Selma, Ünal Edip, Taş Funda Feryal, Demirbilek Hüseyin, Özbek Mehmet Nuri
Diyarbakır Gazi Yaşargil Training and Research Hospital, Clinic of Pediatric Endocrinology, Diyarbakır, Turkey
Diyarbakır Child Diseases Hospital, Clinic of Pediatric Endocrinology, Diyarbakır, Turkey
J Clin Res Pediatr Endocrinol. 2022 Jun 7;14(2):172-178. doi: 10.4274/jcrpe.galenos.2021.2021-10-7. Epub 2022 Jan 11.
The incidence of type 1 diabetes mellitus (T1D) in children has an increasing trend globally, with a variable rate depending on region and ethnicity. Our group first reported T1D incidence in Diyarbakır in 2011. The aim of this study was to evaluate the current incidence rate of pediatric T1D in Diyarbakır, and compare the incidence, and clinical and presenting characteristics of more recent cases with those reported in our first report.
Hospital records of patients diagnosed with T1D in Diyarbakır city between 1 January 2020 and 31 December 2020 and aged under 18 years old were retrieved, and their medical data was extracted. Demographic population data were obtained from address-based census records of the Turkish Statistical Institution (TSI).
Fifty-seven children and adolescents were diagnosed with T1D. Of those, 34 were female (59.6%), indicating a male/female ratio of 1.47. The mean age at diagnosis was 9.5±3.9 years (0.8-17.9). TSI data indicated a population count of 709,803 for the 0-18 years age group. Thus the T1D incidence was 8.03/10 in the 0-18 age group and was higher in the 0-14 age group at 9.14/10. The cumulative increase in the incidence of T1D in the 0-14 age group was 26.9% suggesting an increasing rate of 2.7% per year. The frequency of presentation with diabetic ketoacidosis was 64.9%.
The annual incidence of pediatric T1D in Diyarbakır city increased from 7.2/10 to 9.14/10 within the last decade. The rate of annual increase was 2.7% in the 0-14 age group comparing this study with our earlier report, with a predominance in male subjects and a shift of peak incidence from the 5-9 year age group in the first study to the 10-14 year age group in this one.
全球儿童1型糖尿病（T1D）发病率呈上升趋势，发病率因地区和种族而异。我们团队于2011年首次报告了迪亚巴克尔的T1D发病率。本研究旨在评估迪亚巴克尔目前儿童T1D的发病率，并将近期病例的发病率、临床及表现特征与我们首次报告中的数据进行比较。
检索2020年1月1日至2020年12月31日期间在迪亚巴克尔市诊断为T1D且年龄在18岁以下患者的医院记录，并提取其医疗数据。人口统计学数据来自土耳其统计局（TSI）基于地址的人口普查记录。
57名儿童和青少年被诊断为T1D。其中，34名女性（59.6%），男女比例为1.47。诊断时的平均年龄为9.5±3.9岁（0.8 - 17.9岁）。TSI数据显示，0 - 18岁年龄组的人口数为709,803。因此，0 - 18岁年龄组的T1D发病率为8.03/10万，0 - 14岁年龄组更高，为9.14/10万。0 - 14岁年龄组T1D发病率的累积增幅为26.9%，表明年增长率为2.7%。糖尿病酮症酸中毒的发生率为64.9%。
在过去十年中，迪亚巴克尔市儿童T1D的年发病率从7.2/10万增加到9.14/10万。与我们早期报告相比，0 - 14岁年龄组的年增长率为2.7%，男性为主，发病率高峰从第一项研究中的5 - 9岁年龄组转移到本研究中的10 - 14岁年龄组。
