光氧化还原催化的羟基芳亚胺酮的级联反应，用于构建 3-氨基色酮。
Photoredox-Catalyzed Cascade of Hydroxyarylenaminones to Access 3-Aminated Chromones.
机构信息
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P.R. China.
Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning 530001, P.R. China.
出版信息
J Org Chem. 2022 Jan 21;87(2):1477-1484. doi: 10.1021/acs.joc.1c02796. Epub 2022 Jan 11.
Reported herein is a photoredox-catalyzed amination of hydroxyarylenaminones with -butyl ((perfluoropyridin-4-yl)oxy)carbamate, a versatile amidyl-radical precursor developed in our laboratory. This work establishes a new cascade pathway for the assembly of a range of 3-aminochromones under mild conditions. Downstream transformations of the obtained 3-aminochromones to construct diverse amino pyrimidines greatly broaden the applications of this photocatalyzed protocol.
本文报道了一种光氧化还原催化的羟芳亚胺酮与我们实验室开发的多功能酰基自由基前体 - 丁基 ((全氟吡啶-4-基)氧基) 氨基甲酸酯的胺化反应。这项工作在温和条件下建立了一系列 3-氨基色酮的新型级联途径。获得的 3-氨基色酮的下游转化为构建各种氨基嘧啶极大地拓宽了该光催化方案的应用。
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