Deng Ke-Yi, Wang Zhi-Wei, Xie Zhen-Zhen, He Jun-Tao, Guan Jian-Ping, Chen Kai, Xiang Hao-Yue, Yang Hua
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P. R. China.
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, Henan, P. R. China.
Chem Commun (Camb). 2023 Sep 21;59(76):11401-11404. doi: 10.1039/d3cc03532h.
Development of a new catalytic and straightforward strategy to construct C-N bonds is playing a pivotal role in synthetic chemistry. Here, we report a photocatalysed protocol to access direct C-H amidation of indoles, enabled by a rationally designed -butyl alkyl((perfluoropyridin-4-yl)oxy)carbamate. A series of biologically important aminoindoles were prepared under mild conditions with excellent regioselectivity and broad substrate scope.
开发一种构建C-N键的新型催化直接策略在合成化学中起着关键作用。在此，我们报道了一种光催化方法，可实现吲哚的直接C-H酰胺化反应，该反应由合理设计的-丁基烷基（（全氟吡啶-4-基）氧基）氨基甲酸酯实现。在温和条件下制备了一系列具有重要生物学意义的氨基吲哚，具有优异的区域选择性和广泛的底物范围。
