CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing 100190, P.R. China.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
ACS Appl Bio Mater. 2021 Jan 18;4(1):24-46. doi: 10.1021/acsabm.0c00707. Epub 2020 Jul 27.
Over the past several decades, rapid advances have been made in the application of nanomaterials in the biomedical field including bioimaging and drug delivery. Owing to the natural biocompatibility, diverse design, and dynamic self-assembly, peptides can be used as modules to construct self-assembled peptide-based nanomaterials, which have a high potential in reducing drug toxicity, improving drug targeting, and enhancing drug delivery efficiency. In this review, three typical design strategies of self-assembled peptide nanomaterials for drug delivery have been summarized including ex situ construction, in situ morphological transformation, and in situ construction of peptide drug delivery systems (PDDs). Drugs can be loaded to peptide nanomaterials by physical encapsulation or chemical conjugation methods, showing enhanced retention effects at tumor sites to increase the uptake rate of drugs. Interestingly, drug-free peptide nanomaterials also can be nanomedicines for delivery. These advances implicate the bright prospect of the self-assembled peptide in intelligent nanomedicine and clinical translation.
在过去的几十年中，纳米材料在生物医学领域的应用取得了飞速发展，包括生物成像和药物传递。由于其天然的生物相容性、多样化的设计和动态的自组装，肽可以用作构建自组装肽基纳米材料的模块，在降低药物毒性、提高药物靶向性和增强药物传递效率方面具有很高的应用潜力。在这篇综述中，总结了用于药物传递的自组装肽纳米材料的三种典型设计策略，包括体外构建、原位形态转化和原位构建肽药物传递系统 (PDDs)。药物可以通过物理包封或化学偶联方法负载到肽纳米材料中，在肿瘤部位表现出增强的保留效果，从而提高药物的摄取率。有趣的是，无药物的肽纳米材料也可以作为纳米药物用于传递。这些进展表明自组装肽在智能纳米医学和临床转化方面具有广阔的前景。
