Zhang Yinfeng, Fang Fang, Li Li, Zhang Jinfeng
International Medical Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P. R. China.
Key Laboratory of Molecular Medicine and Biotherapy, School of Life Sciences, Beijing Institute of Technology, Beijing 100811, P. R. China.
ACS Biomater Sci Eng. 2020 Sep 14;6(9):4816-4833. doi: 10.1021/acsbiomaterials.0c00883. Epub 2020 Aug 13.
Over the past few decades, tremendous progress has been made in the development of engineering nanomaterials, which opened new horizons in the field of diagnosis and treatment of various diseases. In particular, self-assembled organic nanomaterials with intriguing features including delicate structure tailoring, facile processability, low cost, and excellent biocompatibility have shown outstanding potential in biomedical applications because of the enhanced permeability and retention (EPR) effect and multifunctional properties. In this review, we briefly introduce distinctive merits of self-assembled organic nanomaterials for biomedical applications. The main focus will be placed on summarizing recent advances in self-assembled organic nanomedicine for drug delivery, bioimaging, and cancer phototherapy, followed by highlighting a critical perspective on further development of self-assembled organic nanomaterials for future clinical translation. We believe that the above themes will appeal to researchers from different fields, including material, chemical, and biological sciences, as well as pharmaceutics.
在过去几十年中，工程纳米材料的发展取得了巨大进展，这为各种疾病的诊断和治疗领域开辟了新的视野。特别是，具有迷人特性的自组装有机纳米材料，包括精细的结构剪裁、易于加工、低成本和出色的生物相容性，由于增强的渗透和滞留（EPR）效应及多功能特性，在生物医学应用中显示出了卓越的潜力。在这篇综述中，我们简要介绍自组装有机纳米材料在生物医学应用中的独特优点。主要重点将放在总结自组装有机纳米药物在药物递送、生物成像和癌症光疗方面的最新进展，随后突出对自组装有机纳米材料未来临床转化进一步发展的批判性观点。我们相信上述主题将吸引来自不同领域的研究人员，包括材料科学、化学、生物学以及药剂学领域的研究人员。
