College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China.
ACS Appl Bio Mater. 2021 Jan 18;4(1):523-532. doi: 10.1021/acsabm.0c01071. Epub 2020 Dec 22.
A poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel film was prepared by bulk polymerization. Then, it was surface modified by perfluorooctanoyl chloride to improve the anti-biofouling properties. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDXS), and atomic force microscopy (AFM) analyses demonstrated that the uniform dense fluorinated layer had been successfully grafted onto pHEMA. The water contact angle (WCA) of the modified pHEMA film increased to 135°, while the surface energy decreased to 13.32 mN/m. The protein and bacterial adhesion properties of the modified pHEMA were decreased significantly. The in vitro cytotoxicity showed that the modified pHEMA was noncytotoxic. Thus, the fluorinated modification on the material surface was a convenient and effective method to establish a hydrophobic and anti-biofouling surface.
一种聚（2-羟乙基甲基丙烯酸酯）（pHEMA）水凝胶膜通过本体聚合制备。然后，通过全氟辛酰氯进行表面改性，以提高抗生物污染性能。衰减全反射傅里叶变换红外（ATR-FTIR）、X 射线光电子能谱（XPS）、扫描电子显微镜-能谱（SEM-EDXS）和原子力显微镜（AFM）分析表明，均匀致密的氟化层已成功接枝到 pHEMA 上。改性 pHEMA 膜的水接触角（WCA）增加到 135°，而表面能降低至 13.32 mN/m。改性 pHEMA 的蛋白质和细菌粘附性能显著降低。体外细胞毒性试验表明，改性 pHEMA 无细胞毒性。因此，材料表面的氟化修饰是建立疏水性和抗生物污染表面的一种方便有效的方法。
