Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, P. R. China.
Cixi Institute of Biomedical Engineering, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices & Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 ZhongGuan West Road, Ningbo 315201, China.
ACS Appl Bio Mater. 2021 Mar 15;4(3):2759-2768. doi: 10.1021/acsabm.0c01663. Epub 2021 Feb 23.
We herein report a facile method to fabricate a multifunctional cancer theranostic nanoplatform via Fe-driven assembly of photosensitizer (chlorine e6, Ce6)-decorated red emissive carbon dots (Ce6-RCDs). The as-prepared Supra-CDs (i.e., CD clusters; also termed as Fe-Ce6-RCDs) are found to not only retain the intrinsic photosensitization, fluorescence (FL), and photothermal properties of the Ce6-RCDs component but also be endowed with the chemodynamic therapy (CDT) function by the introduced Fe the Fenton reaction that can specifically occur in tumor sites. The suitable size (∼36 nm) of the Supra-CDs enables enhanced tumor accumulation, thus achieving significantly improved FL imaging-guided anticancer performance by combining photodynamic, photothermal, and chemodynamic therapeutic modalities. More interestingly, the multi-subcellular structure (including nucleolus and cytoplasm)-targeting capacity of the Supra-CDs further enhances their therapeutic outcomes. This work not only develops a Fe-mediated self-assembly approach to construct a multifunctional cancer theranostic nanoplatform but also emphasizes the ion-interference role of the Fe-mediated CDT in anticancer nanomedicines.
我们在此报告了一种通过 Fe 驱动的光敏剂（氯 e6，Ce6）修饰的红色发光碳点（Ce6-RCDs）组装制备多功能癌症治疗纳米平台的简便方法。所制备的 Supra-CDs（即 CD 簇；也称为 Fe-Ce6-RCDs）不仅保留了 Ce6-RCDs 组分的固有光敏化、荧光（FL）和光热特性，而且通过引入的 Fe 还具有通过 Fenton 反应赋予的化学动力学治疗（CDT）功能，该反应可以在肿瘤部位特异性发生。Supra-CDs 的合适尺寸（约 36nm）可增强肿瘤积累，从而通过结合光动力、光热和化学动力学治疗方式显著提高 FL 成像引导的抗癌性能。更有趣的是，Supra-CDs 的多亚细胞结构（包括核仁区和细胞质）靶向能力进一步增强了它们的治疗效果。这项工作不仅开发了一种 Fe 介导的自组装方法来构建多功能癌症治疗纳米平台，而且还强调了 Fe 介导的 CDT 在抗癌纳米药物中的离子干扰作用。
