Yang Lingyan, Shi Lei, Liu Yihui, Liu Zhenhua, Tian Zejie, Li Hui, Zhang Jiayao, He Jun, Liu Yunmei
Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang City, Hunan Province, 421001, China.
The Second Hospital, University of South China, Hengyang City, Hunan Province, 421001, China.
Curr Med Chem. 2025;32(4):627-646. doi: 10.2174/0109298673264765231006062032.
High concentrations of reactive oxygen species (ROS) can disrupt cell structure and induce apoptosis and necrosis of tumor cells. Photodynamic therapy (PDT) and chemodynamic therapy (CDT) are two cancer treatments mediated by reactive oxygen species. Oxygen molecules (O) are one of the indispensable factors in PDT and hypoxic tumor sites limit its application. However, another ROS-mediated method, CDT, can generate •OH and O by Fenton reaction or Fenton-like reaction. Synergistic PDT/CDT therapy is a strategy to overcome the limitations of tumor microenvironment therapy. In this review, PDT and CDT therapies are briefly introduced, with an emphasis on metal-basrd porphyrin nanoparticles constructed in different ways for PDT/CDT dual-mode therapy. By introducing the history and latest design schemes of the treatment model, it provides ideas for researchers engaged in ROS-mediated cancer therapies.
高浓度的活性氧（ROS）会破坏细胞结构，并诱导肿瘤细胞凋亡和坏死。光动力疗法（PDT）和化学动力疗法（CDT）是两种由活性氧介导的癌症治疗方法。氧分子（O）是PDT中不可或缺的因素之一，而肿瘤缺氧部位限制了其应用。然而，另一种由ROS介导的方法，即CDT，可以通过芬顿反应或类芬顿反应产生•OH和O。协同PDT/CDT疗法是一种克服肿瘤微环境治疗局限性的策略。在这篇综述中，简要介绍了PDT和CDT疗法，重点介绍了以不同方式构建的用于PDT/CDT双模式治疗的金属基卟啉纳米颗粒。通过介绍治疗模式的历史和最新设计方案，为从事ROS介导的癌症治疗研究的人员提供思路。
