3B's Research Group, Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Guimarães 4805-017, Portugal.
ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
ACS Appl Bio Mater. 2021 Apr 19;4(4):2941-2956. doi: 10.1021/acsabm.1c00051. Epub 2021 Apr 2.
This review focuses on vascularization and strategies involved in its evaluation and modulation. Clinical issues associated with engineered tissues of an atomically relevant size that require a vascular network to supply their cells with nutrients and oxygen are analyzed in terms of vascular network formation within scaffolds, which can be produced from varying biomaterials, with the capability of connecting to the vasculature of the patient. Developing angiogenesis techniques and monitoring of angiogenesis development as well as how these methods can be further utilized to tailor vascularization within large tissue engineered constructs are also discussed. Finally, we offer a glimpse toward the future by providing an outlook for vascularization and associated emerging bioprinting concepts in tissue engineering applications.
本文综述了血管生成及其评估和调控策略。本文分析了与原子级相关大小的工程化组织相关的临床问题，这些组织需要血管网络为细胞提供营养和氧气，具体涉及支架内血管网络的形成，支架可由各种生物材料制成，具有与患者脉管系统连接的能力。本文还讨论了血管生成技术的发展和血管生成发育的监测，以及如何进一步利用这些方法来调整大型组织工程构建体中的血管化。最后，我们通过展望组织工程应用中血管化和新兴生物打印概念的未来，提供了一个视角。
