Honeycutt Amanda, Breck Andrew, Bass Sarah, Esposito Dominick
RTI International, Health Economics Program, Research Triangle Park, Durham, NC 27709-2194, USA.
Insight Policy Research, Arlington, VA 22209, USA.
J Comp Eff Res. 2022 Feb;11(2):79-88. doi: 10.2217/cer-2021-0063. Epub 2022 Jan 11.
To estimate the impact of universal anti-TNF therapy in patients with moderate-to-severe Crohn's disease. Developed a population-level Markov model to estimate the impact on health outcomes and medical expenditures of expanding anti-TNF therapy use versus current treatment practices. Reductions in deaths (2600), hip fractures (980), major adverse cardiac events (2700) and patient out-of-pocket medical spending (2%) over 5 years. Total societal costs would be US$22,100 higher per patient per year, primarily due to the high cost of anti-TNF therapy. Expanding anti-TNF therapy use among US adult patients with moderate-to-severe Crohn's disease would reduce morbidity and mortality, decrease disease-related medical costs and increase treatment costs compared with current practice. Despite the higher costs, this approach could substantially benefit patients.
