UMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands.
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Int J Stroke. 2022 Dec;17(10):1100-1106. doi: 10.1177/17474930211069004. Epub 2022 Jan 11.
Preventive screening for intracranial aneurysms is effective in persons with a positive family history of aneurysmal subarachnoid hemorrhage (aSAH), but for many relatives of aSAH patients, it can be difficult to assess whether their relative had an aSAH or another type of stroke.
We aimed to develop a family history questionnaire for people in the population who believe they have a first-degree relative who had a stroke and to assess its accuracy to identify relatives of aSAH patients.
A questionnaire to distinguish between aSAH and other stroke types (ischemic stroke and intracerebral hemorrhage) was developed by a team of clinicians and consumers. The level of agreement between the questionnaire outcome and medical diagnosis was pilot tested in 30 previously admitted aSAH patients. Next, the sensitivity and specificity of the questionnaire were assessed in 91 first-degree relatives (siblings/children) of previously admitted stroke patients.
All 30 aSAH patients were identified by the questionnaire in the pilot study; 29 of 30 first-degree relatives of aSAH patients were correctly identified. The questionnaire had a sensitivity of 97% (95% confidence interval (CI) = 83-100%) and a specificity of 93% (95% CI = 84-98%) when tested in the first-degree relatives of stroke patients.
Our questionnaire can help persons to discriminate an aSAH from other types of stroke in their affected relative. This family history questionnaire is developed in the Netherlands but could also be used in other countries after validation.
对于有蛛网膜下腔出血（aSAH）阳性家族史的人，预防性筛查颅内动脉瘤是有效的，但对于许多 aSAH 患者的亲属来说，很难确定他们的亲属是否患有 aSAH 或其他类型的中风。
我们旨在为认为自己有一级亲属患有中风的人群开发一种家族史问卷，并评估其识别 aSAH 患者亲属的准确性。
由一组临床医生和消费者开发了一种用于区分 aSAH 和其他中风类型（缺血性中风和脑出血）的问卷。该问卷的结果与医疗诊断之间的一致性在 30 名先前住院的 aSAH 患者中进行了试点测试。接下来，在 91 名先前住院的中风患者的一级亲属（兄弟姐妹/子女）中评估了问卷的敏感性和特异性。
在试点研究中，该问卷正确识别了 30 名 aSAH 患者中的所有患者；29 名 aSAH 患者的一级亲属被正确识别。当在中风患者的一级亲属中进行测试时，该问卷的敏感性为 97%（95%置信区间（CI）=83-100%），特异性为 93%（95%CI=84-98%）。
我们的问卷可以帮助人们在受影响的亲属中区分 aSAH 与其他类型的中风。该家族史问卷是在荷兰开发的，但在验证后也可在其他国家使用。
