College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, PR China.
School of Chemical Engineering, Changchun University of Technology, Changchun Jilin 130012, PR China.
Biomater Sci. 2022 Feb 15;10(4):960-969. doi: 10.1039/d1bm01819a.
With the long-term widespread overuse of antibiotics, a large number of antibiotic-resistant bacteria have emerged and become a serious threat to healthcare systems. As an alternative strategy, near-infrared light (NIR)-actuated photothermal treatment has been developed for killing antibiotic-resistant bacteria. Although promising, the widespread applications of photothermal antibacterial platforms face great challenges due to the skin-harmful high laser irradiation. In this work, a novel NIR-responsive hydrogel membrane for effective photothermal sterilization upon light irradiation at skin-permissible intensity has been successfully prepared using a sodium alginate-based hydrogel membrane containing tannic acid-Fe(III) compounds (STF). The as-prepared STF displayed excellent mechanical capacity and fabricability. More importantly, the as-prepared STF revealed superior photothermal efficiency under a low-intensity NIR irradiation (0.3 W cm), which was below the maximum permissible exposure of skin (0.33 W cm). In addition, the STF showed the excellent performance of photothermal sterilization for MRSA both and . Furthermore, the STF showed good biocompatibility. Based on the simple synthesis method, outstanding mechanical properties, excellent photothermal sterilization performance and good biocompatibility, the STF could be a promising wound dressing for antibiotic-resistant bacterial infections.
由于抗生素的长期广泛过度使用，大量的抗生素耐药菌已经出现，这对医疗保健系统构成了严重威胁。作为一种替代策略，近红外光（NIR）驱动的光热疗法已被开发出来用于杀死抗生素耐药菌。尽管很有前景，但由于皮肤有害的高强度激光照射，光热抗菌平台的广泛应用面临着巨大的挑战。在这项工作中，成功地使用含有单宁酸-Fe(III)化合物（STF）的基于海藻酸钠的水凝胶膜制备了一种新型的 NIR 响应水凝胶膜，用于在可允许的皮肤强度的光照射下进行有效的光热杀菌。所制备的 STF 表现出优异的机械性能和可加工性。更重要的是，所制备的 STF 在低强度 NIR 照射（0.3 W cm）下表现出优异的光热效率，低于皮肤的最大允许暴露量（0.33 W cm）。此外，STF 对 MRSA 和 均表现出优异的光热杀菌性能。此外，STF 还表现出良好的生物相容性。基于简单的合成方法、优异的力学性能、优异的光热杀菌性能和良好的生物相容性，STF 有望成为治疗抗生素耐药菌感染的一种有前途的伤口敷料。
