Low-intensity near-infrared light-triggered spatiotemporal antibiotics release and hyperthermia by natural polysaccharide-based hybrid hydrogel for synergistic wound disinfection.

Photothermal sterilization is a promising and effective treatment method in treating bacterial infection. Generally, a widely employed light source in photothermal sterilization inevitably damages the skin tissue due to the high-intensity irradiation dose. How to provide useful antibacterial outcomes without light-triggered skin damage is a challenge for photothermal sterilization. In this work, a novel antibacterial hydrogel (VAT hydrogel, the abbreviation for vancomycin-agarose-ferric tannate hydrogel) has been successfully constructed by the natural polysaccharide hydrogel (AG) encapsulating ferric tannate (TA-Fe) nanoparticles and vancomycin. The VAT hydrogel exhibited the outstanding photothermal properties and controllable antibiotics release. With the results of antibacterial assays, the VAT hydrogel revealed the superior effectiveness of synergistic wound disinfection by the low-intensity near-infrared light-triggered spatiotemporal antibiotics release and hyperthermia. More importantly, the VAT hydrogels possessed the good biocompatibility. With the outstanding synergistic sterilizing effect and excellent biocompatibility, the VAT hydrogel would be a promising candidate for bacteria-associated wound infections.