Deng Hongling, Sun Jie, Yu Zhongpeng, Guo Zhihua, Xu Chen
School of Chemical Engineering, Changchun University of Technology, Changchun 130012, PR China.
School of Chemical Engineering, Changchun University of Technology, Changchun 130012, PR China.
Mater Sci Eng C Mater Biol Appl. 2021 Jan;118:111530. doi: 10.1016/j.msec.2020.111530. Epub 2020 Sep 18.
Photothermal sterilization is a promising and effective treatment method in treating bacterial infection. Generally, a widely employed light source in photothermal sterilization inevitably damages the skin tissue due to the high-intensity irradiation dose. How to provide useful antibacterial outcomes without light-triggered skin damage is a challenge for photothermal sterilization. In this work, a novel antibacterial hydrogel (VAT hydrogel, the abbreviation for vancomycin-agarose-ferric tannate hydrogel) has been successfully constructed by the natural polysaccharide hydrogel (AG) encapsulating ferric tannate (TA-Fe) nanoparticles and vancomycin. The VAT hydrogel exhibited the outstanding photothermal properties and controllable antibiotics release. With the results of antibacterial assays, the VAT hydrogel revealed the superior effectiveness of synergistic wound disinfection by the low-intensity near-infrared light-triggered spatiotemporal antibiotics release and hyperthermia. More importantly, the VAT hydrogels possessed the good biocompatibility. With the outstanding synergistic sterilizing effect and excellent biocompatibility, the VAT hydrogel would be a promising candidate for bacteria-associated wound infections.
光热杀菌是一种治疗细菌感染的有前景且有效的治疗方法。一般来说，光热杀菌中广泛使用的光源由于高强度的辐照剂量不可避免地会损伤皮肤组织。如何在不造成光引发的皮肤损伤的情况下实现有效的抗菌效果是光热杀菌面临的一项挑战。在这项工作中，一种新型抗菌水凝胶（VAT水凝胶，即万古霉素 - 琼脂糖 - 单宁酸铁水凝胶的缩写）已通过天然多糖水凝胶（AG）包裹单宁酸铁（TA - Fe）纳米颗粒和万古霉素成功构建。VAT水凝胶展现出出色的光热性能和可控的抗生素释放。通过抗菌试验结果表明，VAT水凝胶通过低强度近红外光触发的时空抗生素释放和热疗展现出协同伤口消毒的卓越效果。更重要的是，VAT水凝胶具有良好的生物相容性。凭借出色的协同杀菌效果和优异的生物相容性，VAT水凝胶有望成为治疗细菌相关伤口感染的候选材料。
