Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Eur Arch Otorhinolaryngol. 2022 Oct;279(10):4727-4733. doi: 10.1007/s00405-021-07246-x. Epub 2022 Jan 11.
The hearing outcome of idiopathic sudden sensorineural hearing loss (ISSNHL) is hard to predict. We herein constructed a multiple regression model for hearing outcomes in each frequency separately in an attempt to achieve practical prediction in ISSNHL.
We enrolled 235 consecutive in-patients with ISSNHL who were treated in our department from 2015 to 2020 (average hearing level at 250-4000 Hz ≥ 40 dB; time from onset to treatment ≤ 14 days; 126 males/109 females; age range 17-87 years (average 61.0 years)). All patients received systemic prednisolone administration combined with intratympanic dexamethasone injection. The pure-tone hearing threshold of 125-8000 Hz was measured at every octave before (HL) and after (HL) treatment. A multiple regression model was constructed for HL (dependent variable) using five explanatory variables (age, days from onset to treatment, presence of vertigo, HL, and hearing level of the contralateral ear).
The multiple correlation coefficient increased as the frequency increased. Strong correlations were seen in high frequencies, with multiple correlation coefficients of 0.784/0.830 for 4000/8000 Hz. The width of the 70% prediction interval was narrower for 4000/8000 Hz (± 18.2/16.3 dB) than for low to mid-frequencies. Among the five explanatory variables, HL showed the largest partial correlation coefficient for any frequency. The partial correlation coefficient for HL increased as the frequency increased, which may partially explain the high multiple correlation coefficients for high frequencies.
The present model would be of practical use for predicting hearing outcomes in high frequencies in patients with ISSNHL.
特发性突发性聋（ISSNHL）的听力预后难以预测。本研究旨在建立一个多回归模型，以分别预测每个频率的听力结果，试图在 ISSNHL 中实现实用的预测。
我们纳入了 2015 年至 2020 年在我科接受治疗的 235 例连续 ISSNHL 住院患者（250-4000Hz 平均听阈≥40dB；发病至治疗时间≤14 天；男性 126 例，女性 109 例；年龄 17-87 岁，平均 61.0 岁）。所有患者均接受全身泼尼松龙治疗联合鼓室内地塞米松注射。治疗前（HL）和治疗后（HL）每 1 个倍频程测量 125-8000Hz 的纯音听阈。使用 5 个解释变量（年龄、发病至治疗时间、眩晕、HL 和对侧耳听力水平）构建用于 HL（因变量）的多回归模型。
随着频率的增加，多元相关系数增加。在高频时相关性较强，4000/8000Hz 的多元相关系数分别为 0.784/0.830。4000/8000Hz 的 70%预测区间宽度较低频至中频更窄（±18.2/16.3dB）。在五个解释变量中，HL 对任何频率的偏相关系数最大。HL 的偏相关系数随着频率的增加而增加，这可能部分解释了高频时多元相关系数较高的原因。
本模型对预测 ISSNHL 患者高频听力结果具有实际应用价值。
