Pasteur Institute of Iran, Tehran, Iran.
Canadian College of Naturopathic Medicine, Toronto, ON, Canada.
Adv Exp Med Biol. 2021;1343:135-160. doi: 10.1007/978-3-030-80983-6_9.
Systems biology is an emerging discipline in the post-genomic era, increasingly have been applied in bioscience and molecular medicine. The aim of this research field is a systems-level understanding of biological phenomena. In the same vein, a holistic approach to the classification of wellbeing and treatment of illnesses has been applied in traditional medicines. This chapter summarizes available research on biological differences between hot and cold in multiple traditional medicines by integrating modern biomedical data and concept-rich traditional medicines. In general, inflammation, immune-related pathways and higher metabolism are reported in hot individuals. While, lower metabolism have been observed in cold people. The interdisciplinary nature of systems biology studies can provide better insights into traditional medicines' physiopathology, fill the gap between traditional medicines and modern biological language, and facilitate drug discovery and individualized treatments.
系统生物学是后基因组时代新兴的学科，越来越多地应用于生物科学和分子医学。该研究领域的目的是在系统水平上理解生物现象。同样地，传统医学也采用了整体方法来对健康和疾病进行分类和治疗。本章通过整合现代生物医学数据和富含概念的传统医学，总结了多种传统医学中关于寒热生物差异的现有研究。一般来说，热体质的人表现出炎症、免疫相关途径和更高的代谢水平。而寒体质的人则表现出较低的代谢水平。系统生物学研究的跨学科性质可以为传统医学的病理生理学提供更好的见解，弥合传统医学和现代生物学语言之间的差距，并促进药物发现和个体化治疗。
