Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China.
College of Materials Science, Qiqihar University, Qiqihar 161006, P. R. China.
ACS Appl Mater Interfaces. 2022 Jan 26;14(3):3809-3824. doi: 10.1021/acsami.1c21307. Epub 2022 Jan 11.
The local hyperthermia (>41 °C) effect of photothermal therapy (PTT) is significantly limited by the efficiency of PTT agents to convert laser energy to heat, and such oncotherapy, similar to conventional chemotherapy, invariably encounters the challenge of nonspecific application. Undue reliance on oxygen sources still poses particular difficulties in photodynamic therapy (PDT) for deep-level clinical applications. Considering these therapeutic issues, in this study, we constructed a versatile but unique nanosystem by encapsulating Au nanosheets in codoped gadolinium oxyfluoride (GdOF):Yb,Er spheres, followed by decoration of a chemotherapeutic drug (doxorubicin), photosensitizer (rose Bengal, RB), and targeted agent (folic acid). This allowed the incorporation of cancer treatment and real-time curative efficacy monitoring into one single theranostic nanoplatform. Benefiting from the dual contribution of the strong absorptions in the NIR-I and NIR-II regions, relevant photothermal-conversion efficiency (η) values pertaining to that final product were 39.2% at 1064 nm irradiation and 35.7% at 980 nm illumination. The fluorescence resonance energy transfer that occurred in the up-converted GdOF:Yb,Er to RB contributed to the high PDT efficacy. Combined with a micromeric acid-responsive drug release in a targeted tumor microenvironment, high-performance synergistic therapy was realized. In addition, up-conversion fluorescence imaging and computed tomography imaging accompanied by multimodal magnetic resonance imaging were simultaneously achieved owing to the doped lanthanide ions and the encapsulated Au nanosheets. Our designed oncotherapy nanosystem provides an alternative strategy to acquire ideal theranostic effects.
光热疗法（PTT）的局部高热（>41°C）效应受到 PTT 剂将激光能量转化为热量的效率的显著限制，这种肿瘤治疗方法与传统化疗类似，不可避免地面临非特异性应用的挑战。对氧源的过度依赖仍然给深层临床应用的光动力疗法（PDT）带来了特殊的困难。考虑到这些治疗问题，在本研究中，我们通过在共掺杂的钆氧氟化物（GdOF）：Yb、Er 球体内封装金纳米片，然后修饰化疗药物（阿霉素）、光敏剂（孟加拉玫瑰红，RB）和靶向剂（叶酸），构建了一种通用但独特的纳米系统。这使得癌症治疗和实时疗效监测能够纳入一个单一的治疗诊断纳米平台。受益于近红外-I 和近红外-II 区域的强吸收，该最终产物的相关光热转换效率（η）值在 1064nm 照射下为 39.2%，在 980nm 照射下为 35.7%。上转换 GdOF：Yb、Er 到 RB 的荧光共振能量转移有助于实现高 PDT 疗效。结合靶向肿瘤微环境中的微酸响应药物释放，实现了高性能协同治疗。此外，由于掺杂的镧系离子和封装的金纳米片，实现了上转换荧光成像和计算机断层扫描成像以及多模态磁共振成像的同时实现。我们设计的肿瘤治疗纳米系统提供了一种获得理想治疗诊断效果的替代策略。
