Key Laboratory of Superlight Materials and Surface Technology, College of Materials Science and Chemical Engineering, Ministry of Education, Harbin Engineering University, Harbin 150001, P. R. China.
ACS Appl Mater Interfaces. 2022 Jan 19;14(2):2650-2662. doi: 10.1021/acsami.1c23174. Epub 2022 Jan 7.
Smart nanotheranostic systems (SNSs) have attracted extensive attention in antitumor therapy. Nevertheless, constructing SNSs with disease diagnosis ability, improved drug delivery efficiency, inherent imaging performance, and high treatment efficiency remains a scientific challenge. Herein, ultrasmall tin dioxide (SnO) was assembled with upconversion nanoparticles (UCNPs) to form mesoporous nanocapsules by an hydrothermal deposition method, followed by loading with doxorubicin (DOX) and modification with bovine serum albumin (BSA). pH/near-infrared dual-responsive nanotheranostics was constructed for computed tomography (CT) and magnetic resonance (MR) imaging-induced collaborative cancer treatment. The mesoporous channel of SnO was utilized as a reservoir to encapsulate DOX, an antineoplastic drug, for chemotherapy and as a semiconductor photosensitizer for photodynamic therapy (PDT). Furthermore, the DOX-loaded UCNPs@SnO-BSA nanocapsules combined PDT, Nd-doped UCNP-triggered hyperthermia effect, and DOX-triggered chemotherapy simultaneously and demonstrated prominently enhanced treatment efficiency compared to the monotherapy model. Moreover, tin, as one of the trace elements in the human body, has a similar X-ray attenuation coefficient to iodine and therefore can act as a contrast agent for CT imaging to monitor the treatment process. Such an orchestrated synergistic anticancer treatment exhibited apparent inhibition of tumor growth in tumor-bearing mice with negligible side effects. Our study demonstrates nanocapsules with excellent biocompatibility and great potential for cancer treatment.
智能纳米诊疗系统（SNSs）在抗肿瘤治疗中受到广泛关注。然而，构建具有疾病诊断能力、提高药物递送效率、固有成像性能和高治疗效率的 SNSs 仍然是一个科学挑战。在此，采用水热沉积法将超小氧化锡（SnO）与上转换纳米粒子（UCNPs）组装成介孔纳米胶囊，然后负载阿霉素（DOX）并进行牛血清白蛋白（BSA）修饰。构建了 pH/近红外双重响应纳米诊疗剂，用于计算机断层扫描（CT）和磁共振（MR）成像诱导的协同癌症治疗。SnO 的介孔通道被用作储库，用于封装阿霉素（一种抗癌药物）进行化学治疗，以及用作光动力治疗（PDT）的半导体光敏剂。此外，载 DOX 的 UCNPs@SnO-BSA 纳米胶囊联合 PDT、掺钕 UCNP 触发的热疗效应和 DOX 触发的化学治疗，与单一治疗模型相比，表现出明显增强的治疗效果。此外，锡作为人体中的微量元素之一，具有与碘相似的 X 射线衰减系数，因此可用作 CT 成像的造影剂来监测治疗过程。这种协调的协同抗癌治疗在荷瘤小鼠中表现出明显的抑制肿瘤生长作用，且副作用极小。我们的研究表明，这种具有优异生物相容性和巨大癌症治疗潜力的纳米胶囊。
