Farid Mariam F, S Abouelela Yara, Rizk Hamdy
Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.
Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.
Auton Neurosci. 2022 Mar;238:102932. doi: 10.1016/j.autneu.2021.102932. Epub 2021 Dec 30.
Spinal cord injury (SCI) is a serious neurological spinal cord damage that resulted in the loss of temporary or permanent function. However, there are even now no effective therapies for it. So, a new medical promising therapeutic hotspot over the previous decades appeared which was (Stem cell (SC) cure of SCI). Otherwise, animal models are considered in preclinical research as a model for humans to trial a potential new treatment.
Following articles were saved from different databases (PubMed, Google scholar, Egyptian knowledge bank, Elsevier, Medline, Embase, ProQuest, BMC) on the last two decades, and data were obtained then analyzed.
This review discusses the type and grading of SCI. As well as different types of stem cells therapy for SCI, including mesenchymal stem cells (MSCs), neural stem cells (NSCs), hematopoietic stem cells (HSCs), induced pluripotent stem cells (iPSCs), and embryonic stem cells (ESCs). The review focuses on the transplantation pathways, clinical evaluation, and clinical signs of different types of SC on different animal models which are summarized in tables to give an easy to reach.
Pharmacological and physiotherapy have limited regenerative power in comparison with stem cells medication in the treatment of SCI. Among several sources of cell therapies, mesenchymal stromal/stem cell (MSC) one is being progressively developed as a trusted important energetic way to repair and regenerate. Finally, a wide-ranged animal models have been condensed that helped in human clinical trial therapies.
脊髓损伤（SCI）是一种严重的脊髓神经损伤，会导致暂时或永久性的功能丧失。然而，目前尚无有效的治疗方法。因此，在过去几十年中出现了一个新的医学上有前景的治疗热点，即（干细胞治疗SCI）。此外，动物模型在临床前研究中被视为人类试验潜在新疗法的模型。
从过去二十年的不同数据库（PubMed、谷歌学术、埃及知识库、爱思唯尔、医学在线、荷兰医学文摘数据库、ProQuest、生物医学中心）中检索文章，并获取数据进行分析。
本综述讨论了SCI的类型和分级。以及用于SCI的不同类型的干细胞疗法，包括间充质干细胞（MSC）、神经干细胞（NSC）、造血干细胞（HSC）、诱导多能干细胞（iPSC）和胚胎干细胞（ESC）。综述重点关注不同类型干细胞在不同动物模型上的移植途径、临床评估和临床体征，并汇总在表格中以便于查阅。
与干细胞药物治疗SCI相比，药物治疗和物理治疗的再生能力有限。在多种细胞治疗来源中，间充质基质/干细胞（MSC）正逐渐发展成为一种可靠的重要修复和再生途径。最后，总结了广泛的动物模型，这有助于人类临床试验治疗。
