Boyle William S, Chen Weili, Rodriguez Astrid, Linn Samantha, Tolar Jakub, Lozano Karen, Reineke Theresa M
Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Stem Cell Institute and Division of Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, United States.
ACS Appl Bio Mater. 2019 Feb 18;2(2):619-624. doi: 10.1021/acsabm.8b00690. Epub 2019 Feb 5.
Recessive dystrophic epidermolysis bullosa (RDEB), an inherited disease featuring blistering wounds, causes constant inflammation that leads to the eventual development of an aggressive form of squamous cell carcinoma (RDEB SCC). The persistence of inflammatory chemokines such as MCP-1 and Il-8 in RDEB wounds may foster RDEB SCC carcinogenesis. We report the production of ternary composite nanofibers containing pullulan, chondroitin sulfate, and tannic acid as RDEB wound dressings. The swellable fibers are stable to hydration and absorb ∼500% their weight in water. The fibers remove ∼99% of MCP-1 from solution in <2 h. Scavenged media did not promote RDEB SCC migration.
隐性营养不良性大疱性表皮松解症（RDEB）是一种以水疱性伤口为特征的遗传性疾病，会引发持续炎症，最终导致侵袭性鳞状细胞癌（RDEB SCC）的发展。RDEB伤口中炎性趋化因子如MCP-1和Il-8的持续存在可能促进RDEB SCC的致癌作用。我们报道了含有支链淀粉、硫酸软骨素和单宁酸的三元复合纳米纤维作为RDEB伤口敷料的制备。这种可膨胀纤维在水化过程中稳定，能吸收约为其重量500%的水分。这些纤维在不到2小时内可从溶液中去除约99%的MCP-1。清除后的培养基不会促进RDEB SCC迁移。
