Marjuban Shaik Merkatur Hakim, Rahman Musfira, Duza Syeda Sharmin, Ahmed Mohammad Boshir, Patel Dinesh K, Rahman Md Saifur, Lozano Karen
Department of Materials Science and Engineering, Texas A&M University, College Station, TX 77843, USA.
Department of Mechanical Engineering, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.
Polymers (Basel). 2023 Mar 1;15(5):1253. doi: 10.3390/polym15051253.
Over the last decade, researchers have investigated the potential of nano and microfiber scaffolds to promote wound healing, tissue regeneration, and skin protection. The centrifugal spinning technique is favored over others due to its relatively straightforward mechanism for producing large quantities of fiber. Many polymeric materials have yet to be investigated in search of those with multifunctional properties that would make them attractive in tissue applications. This literature presents the fundamental process of fiber generation, and the effects of fabrication parameters (machine, solution) on the morphologies such as fiber diameter, distribution, alignment, porous features, and mechanical properties. Additionally, a brief discussion is presented on the underlying physics of beaded morphology and continuous fiber formation. Consequently, the study provides an overview of the current advancements in centrifugally spun polymeric fiber-based materials and their morphological features, performance, and characteristics for tissue engineering applications.
在过去十年中，研究人员一直在研究纳米和微纤维支架在促进伤口愈合、组织再生和皮肤保护方面的潜力。离心纺丝技术因其生产大量纤维的机制相对简单而比其他技术更受青睐。许多聚合材料尚未得到研究，以寻找具有多功能特性、使其在组织应用中具有吸引力的材料。本文介绍了纤维生成的基本过程，以及制造参数（机器、溶液）对诸如纤维直径、分布、排列、多孔特征和机械性能等形态的影响。此外，还简要讨论了串珠形态和连续纤维形成的基本物理原理。因此，本研究概述了基于离心纺丝聚合物纤维的材料及其形态特征、性能和在组织工程应用中的特性的当前进展。
