Department of Biotechnology, Dr. B.C. Guha Centre for Genetic Engineering and Biotechnology, Faculty of Science, University of Calcutta, Kolkata, India.
Protein Pept Lett. 2022;29(3):208-217. doi: 10.2174/0929866529666220110143520.
Being an essential enzyme in protein synthesis, the aminoacyl-tRNA synthetases (aaRSs) have a conserved function throughout evolution. However, research has uncovered altered expressions as well as interactions of aaRSs, in league with aaRS-interacting multi-functional proteins (AIMPs), forming a multi-tRNA synthetase complex (MSC) and divulging into their roles outside the range of protein synthesis. In this review, we have directed our focus into the rudimentary structure of this compact association and also how these aaRSs and AIMPs are involved in the maintenance and progression of lung cancer, the principal cause of most cancer-related deaths. There is substantial validation that suggests the crucial role of these prime housekeeping proteins in lung cancer regulation. Here, we have addressed the biological role that the three AIMPs and the aaRSs play in tumorigenesis, along with an outline of the different molecular mechanisms involved in the same. In conclusion, we have introduced the potentiality of these components as possible therapeutics for the evolution of new-age treatments of lung tumorigenesis.
作为蛋白质合成中的必需酶，氨酰-tRNA 合成酶（aaRSs）在进化过程中具有保守的功能。然而，研究已经揭示了 aaRSs 的表达改变以及与 aaRS 相互作用的多功能蛋白（AIMPs）的相互作用，形成多 tRNA 合成酶复合物（MSC），并揭示了它们在蛋白质合成范围之外的作用。在这篇综述中，我们将注意力集中在这种紧密结合的关联的基本结构上，以及这些 aaRSs 和 AIMPs 如何参与肺癌的维持和进展，肺癌是大多数癌症相关死亡的主要原因。有大量证据表明，这些主要的管家蛋白在肺癌的调控中起着至关重要的作用。在这里，我们探讨了三种 AIMPs 和 aaRSs 在肿瘤发生中的生物学作用，并概述了其中涉及的不同分子机制。总之，我们介绍了这些成分作为治疗肺癌肿瘤发生的新方法的潜在可能性。
