Department of Zoology, Triveni Devi Bhalotia College, Raniganj, Paschim Bardhaman 713 347, West Bengal, India.
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Hombegowda Nagar, Bengaluru 560029, India.
Life Sci. 2022 Feb 15;291:120316. doi: 10.1016/j.lfs.2022.120316. Epub 2022 Jan 10.
Growth hormone secretagogue receptor type 1A (GHSR-1A) is a functional receptor of orexigenic peptide ghrelin and is highly expressed in mesolimbic dopaminergic systems that regulate incentive value of artificial reward in substance abuse. Interestingly, GHSR-1A has also shown ligand-independent constitutive activity. Alcohol use disorder (AUD) is one of the growing concerns worldwide as it involves complex neuro-psycho-endocrinological interactions. Positive correlation of acylated ghrelin and alcohol-induced human brain response in the right and left ventral striatum are evident. In the last decade, the beneficial effects of ghrelin receptor (GHSR-1A) antagonism to suppress artificial reward circuitries and induce self-control for alcohol consumption have drawn significant attention from researchers. In this updated review, we summarize the available recent preclinical, clinical, and experimental data to discuss functional, molecular actions of central ghrelin-GHSR-1A signaling in different craving levels for alcohol as well as to promote "GHSR-1A antagonism" as one of the potential therapies in early abstinence.
生长激素促分泌素受体 1A（GHSR-1A）是一种促食欲肽 ghrelin 的功能性受体，在调节物质滥用中人工奖励的激励价值的中脑边缘多巴胺能系统中高度表达。有趣的是，GHSR-1A 也表现出配体非依赖性组成型活性。酒精使用障碍（AUD）是全球日益关注的问题之一，因为它涉及复杂的神经心理内分泌相互作用。酰化 ghrelin 与酒精诱导的人类大脑反应在右侧和左侧腹侧纹状体之间的正相关是明显的。在过去的十年中，ghrelin 受体（GHSR-1A）拮抗剂抑制人工奖励回路并诱导自我控制饮酒的有益效果引起了研究人员的极大关注。在本次更新的综述中，我们总结了现有的最近的临床前、临床和实验数据，以讨论中枢 ghrelin-GHSR-1A 信号在不同酒精渴求水平下的功能和分子作用，并促进“GHSR-1A 拮抗作用”作为早期禁欲的潜在治疗方法之一。
