Department of Ageing and Therapeutics, University Hospital Limerick, Dooradoyle, Limerick, Ireland
Department of Ageing and Therapeutics, University Hospital Limerick, Dooradoyle, Limerick, Ireland.
BMJ Open. 2022 Jan 11;12(1):e049216. doi: 10.1136/bmjopen-2021-049216.
Frailty is associated with adverse outcomes relating to cardiac procedures. It has been proposed that frailty scoring should be included in the preoperative assessment of patients undergoing aortic valve replacement. We aim to examine the Rockwood Clinical Frailty Scale (CFS), as a predictor of adverse outcomes following aortic valve replacement.
Prospective and retrospective cohort studies and randomised controlled trials assessing both the preoperative frailty status (as per the CFS) and incidence of adverse outcomes among older adults undergoing either surgical aortic valve replacement or transcatheter aortic valve replacement will be included. Adverse outcomes will include mortality and periprocedural complications, as well as a composite of 30-day complications. A search will be conducted from 2005 to present using a prespecified search strategy. Studies will be screened for inclusion by two reviewers, with methodological quality assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. Relative risk ratios with 95% CIs will be generated for each outcome of interest, comparing frail with non-frail groups. Data will be plotted on forest plots where applicable. The quality of the evidence will be determined using the Grading of Recommendations, Assessment, Development and Evaluation tool.
Ethical approval is not required for this study as no primary data will be collected. We will publish the review in a peer-reviewed journal on completion.
CRD42020213757.
衰弱与心脏手术相关的不良结局有关。有人提出，在评估接受主动脉瓣置换术的患者时，应将衰弱评分纳入术前评估。我们旨在研究 Rockwood 临床衰弱量表（CFS），作为预测主动脉瓣置换术后不良结局的指标。
将纳入前瞻性和回顾性队列研究以及随机对照试验，评估老年人行外科主动脉瓣置换术或经导管主动脉瓣置换术的术前衰弱状态（根据 CFS）和不良结局发生率。不良结局将包括死亡率和围手术期并发症，以及 30 天并发症的综合指标。将使用预设的搜索策略，从 2005 年至今进行搜索。将由两名评审员对研究进行筛选，以纳入标准评估方法学质量，使用诊断准确性研究的质量评估（QUADAS-2）工具。将为每个感兴趣的结局生成脆弱与非脆弱组之间的相对风险比及其 95%置信区间。在适用的情况下，将数据绘制成森林图。使用推荐评估、制定和评估工具来确定证据的质量。
由于本研究不收集原始数据，因此不需要伦理批准。研究完成后，我们将在同行评议的期刊上发表综述。
PROSPERO 注册号：CRD42020213757。
