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周围神经再生的神经科学

Neuroscience of Peripheral Nerve Regeneration.

作者信息

Paramel Mohan Sunil, Ramalingam Murugan

机构信息

Department of Oral and Maxillofacial Pathology, Sree Anjaneya Institute of Dental Sciences, Kozhikode, Kerala, India.

Department of Stems Cells and Regenerative Medicine, Malabar Medical College Hospital and Research Centre, Kozhikode, Kerala, India.

出版信息

J Pharm Bioallied Sci. 2021 Nov;13(Suppl 2):S913-S916. doi: 10.4103/jpbs.jpbs_182_21. Epub 2021 Nov 10.

DOI:10.4103/jpbs.jpbs_182_21
PMID:35017897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8686930/
Abstract

Peripheral nerve injury involves complex molecular, cellular, and genetic events that help in ultimate regeneration of nerve. Some key factors are upregulated and some downregulated in the process of regeneration of nerve to attain almost perfect architecture. This review renders short overview about how the injured neurons and supporting cells like Schwann cells help in creating ample microenvironment for regeneration of peripheral nerve and their maturation.

摘要

周围神经损伤涉及复杂的分子、细胞和遗传事件，这些事件有助于神经的最终再生。在神经再生过程中，一些关键因素上调，一些关键因素下调，以实现几乎完美的结构。这篇综述简要概述了受损神经元和施万细胞等支持细胞如何帮助为周围神经再生及其成熟创造充足的微环境。

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本文引用的文献

1
Editorial: Peripheral Nerve Regeneration.社论：周围神经再生
Front Cell Neurosci. 2019 Oct 15;13:464. doi: 10.3389/fncel.2019.00464. eCollection 2019.
2
Beyond Trophic Factors: Exploiting the Intrinsic Regenerative Properties of Adult Neurons.超越营养因子：利用成年神经元的内在再生特性
Front Cell Neurosci. 2019 Apr 5;13:128. doi: 10.3389/fncel.2019.00128. eCollection 2019.
3
The Role of BDNF in Peripheral Nerve Regeneration: Activity-Dependent Treatments and Val66Met.脑源性神经营养因子在周围神经再生中的作用：活动依赖性治疗与Val66Met
Front Cell Neurosci. 2019 Jan 11;12:522. doi: 10.3389/fncel.2018.00522. eCollection 2018.
4
Mitochondrial Damage-Associated Molecular Patterns of Injured Axons Induce Outgrowth of Schwann Cell Processes.受损轴突的线粒体损伤相关分子模式诱导雪旺细胞突起生长。
Front Cell Neurosci. 2018 Nov 27;12:457. doi: 10.3389/fncel.2018.00457. eCollection 2018.
5
3D printing strategies for peripheral nerve regeneration.3D 打印在周围神经再生中的策略。
Biofabrication. 2018 Mar 23;10(3):032001. doi: 10.1088/1758-5090/aaaf50.
6
In vitro models for peripheral nerve regeneration.用于周围神经再生的体外模型。
Eur J Neurosci. 2016 Feb;43(3):287-96. doi: 10.1111/ejn.13054. Epub 2015 Sep 28.
7
Functional evaluation of peripheral nerve regeneration and target reinnervation in animal models: a critical overview.动物模型中周围神经再生和靶器官再支配的功能评估：批判性综述。
Eur J Neurosci. 2016 Feb;43(3):271-86. doi: 10.1111/ejn.13033. Epub 2015 Aug 26.
8
Releasing 'brakes' to nerve regeneration: intrinsic molecular targets.释放神经再生的“刹车”：内在分子靶点。
Eur J Neurosci. 2016 Feb;43(3):297-308. doi: 10.1111/ejn.13018. Epub 2015 Aug 14.
9
Schwann Cells: Development and Role in Nerve Repair.施万细胞：发育及其在神经修复中的作用
Cold Spring Harb Perspect Biol. 2015 May 8;7(7):a020487. doi: 10.1101/cshperspect.a020487.
10
Peripheral nerve reconstruction after injury: a review of clinical and experimental therapies.损伤后周围神经重建：临床与实验治疗综述
Biomed Res Int. 2014;2014:698256. doi: 10.1155/2014/698256. Epub 2014 Sep 3.